ESPE Abstracts

Background: In the published literature, eating disorders appear as a cause of pubertal delay/arrest in young girls. Furthermore, several studies associate anorexia nervosa (AN) with epigenetic changes that may heighten the risk of the disorder and lead to clinical signs as functional hypothalamic amenorrhea. In the present study we investigated whether AN correlates with a distinct DNA methylation profile compared to normal-eating pubertal girls.<p class=...

Background: Correct hypothalamo-pituitary (HP) formation is dependent on a complex network of numerous transcription factors and signalling molecules. Congenital hypopituitarism (CH) is a highly variable disorder involving deficiencies in one or more of the 7 pituitary hormones, and is often associated with syndromic features, spanning visual, midline brain, and facial abnormalities.Methods: We used a targeted gene panel...

Background: Spexin (SPX)and kisspeptin (KISS) are peptides involved in the regulation of body weight, metabolism and reproduction.Aim: To assess expression levels ofSPX andKISS in serum, ovarian tissue and white adipose tissue (WAT) of female albino Wistar rats as related to pubertal status and metabolic surrogates of puberty.Materials and Methods: Twenty-six female albino Wistar r...

Paternally inherited mutations in the DLK1 (delta-like non-canonical Notch ligand 1) gene cause central precocious puberty (CPP) with a metabolic phenotype, suggesting that DLK1 (Delta-like 1 homolog/Preadipocyte factor 1) may link pubertal timing with body composition. However, little is known about circulating DKL1 in normal and precocious puberty.Objective: To evaluate longitudinal changes in circulating DLK1 concentrations i...

Introduction: Delayed puberty in boys, defined as lack of pubertal onset by the age of 14 years, is often constitutional and self-limited. However, it can lead to feelings of sadness and anxiety. The long-term health consequences of delayed puberty in males are not well understood.Objective: To study the long-term morbidity in young men exposed to delayed puberty.Methods: All Swedi...

Background/aims: Pilocytic astrocytomas (PA) are low-grade neoplasms that affect the precortical visual pathway and are most commonly detected in children and adolescents, representing 2–5% of childhood central nervous system (CNS) tumours. Optic gliomas (OPGs) can occur sporadically, or in association with neurofibromatosis type 1 (NF1). We assessed the prevalence of endocrine dysfunction in children with PA and evaluated outcomes between subgroups of P...