ESPE Abstracts

The monocarboxylate transporter 8 (MCT8) is essential for transporting thyroid hormones to the brain. MCT8 deficiency occurs in SLC16A2 gene variants; patients usually present with neurological symptoms and are diagnosed with cerebral palsy or central hypothyroidism. Recently, 3,3',5-triiodothyroacetic acid (Triac) is used in treatment. This study aimed to evaluate the diagnosis and follow-up processes of five MCT8 deficiency patients. Five patients with variants in the S...

Background: Thyroid hormone plays a significant role in development and function of many organ systems especially for brain. Understanding the prevalence of thyroid disorders and characteristic of thyroid function tests in preterm infants are important to diagnosis and provide proper management.Objectives: The primary objective is to study the prevalence of thyroid disorders in preterm infants. The secondary objectives a...

Background: Pituitary resistance to exogenous thyroxine (RETH) refers to persistently elevated serum TSH levels despite high/normal T4 concentrations in levothyroxine-treated patients. The underlying mechanisms and natural history of RETH in children with congenital hypothyroidism (CH) are not well known.Objective: We aimed to describe the possible mechanisms and natural history of RETH in children with CH.<p class="...

Background: Hyperthyrotropinaemia (HTT) describes the biochemical condition of elevated thyroid stimulating hormone (TSH) with normal thyroid hormone concentration. The aetiology of this condition is likely multifactorial but factors such as maternal thyroid disease and presence of trisomy 21 (T21) are thought to play an important role. HTT can be identified during newborn screening for congenital hypothyroidism (CHT), or when thyroid investigations are perfor...

The overall remission rate after 2 years of anti-thyroid drug treatment (ATD) in pediatric patients with autoimmune hyperthyroidism (AI) is 20-30%. The European Thyroid Association (ETA) recommends longer duration of ATD therapy in patients who have low likelihood of remission. Older age, female sex, ethnicity, small goiter, mild biochemical derangement at diagnosis, lower TSH receptor antibodies (TRAb) titer, history of other autoimmune conditions, duration of ATD treatment, ...

Background: Shear wave elastography (SWE) is an ultrasound diagnostic method evaluating tissue’s stiffness. It has been demonstrated that the mechanical properties of tissue involved in the pathological process are changed and SWE might indicate regions of the examined tissue covered by the disease. In adults SWE is used to differentiate benign and malignant nodules in thyroid gland, however there are still few studies on application of SWE in thyroid di...