ESPE Abstracts

Inorganic phosphate (Pi) is an essential mineral required for the formation of bone, cell membranes, energy metabolism, storage and transmission of genetic information, cellular signaling events, or acid-base buffering. Diet provides phosphate in various forms ranging from plant-derived phytates with low bioavailability to animal proteins and inorganic phosphate salt with high and very high bioavailability, respectively. Since intestinal absorption of bioavailable phosphate is...

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Pseudohypoparathyroidism, or syndromes associated with PTH resistance, share a common defect in the PTH1R/Gsalpha/cAMP signaling pathway. Therefore, this entity is now labeled as “inactivating PTH/PTHrP disorder” or iPPSD. IPPSD is a genetic disorder characterized by target-organ unresponsiveness to PTH and/or PThrP. it mimics hypoparathyroidism, as patients present with hypocalcemia and hyperphosphatemia; however, due to an abnormal signaling pathway downstream of...