ESPE Abstracts

In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes. We aimed to determine the effect of verapamil on pancreatic beta cell function in children and adolescents with newly diagnosed type 1 diabetes. This double-blind, randomized clinical trial including...

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Cardiovascular disease (CVD) remains the main cause of morbidity and mortality in individuals with type 1 diabetes (T1D). Although the clinical manifestations of CVD are almost exclusively observed in adult life, their incidence represents the result of a long subclinical disease process, which is largely driven by potentially modifiable risk factors, including not only hyperglycaemia but also dyslipidaemia, hypertension, obesity, insulin resistance, lifestyle habits. In indiv...