ESPE Abstracts

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The reproductive axis comprises the hypothalamus, the pituitary gland and the gonads. While all its components are assembled in the embryo, it only starts to be active postnatally, initially during a transient period known as minipuberty. Activity is re-initiated at puberty which marks the onset of reproductive capacity. The hypothalamic gonadotrophin releasing hormone (GnRH) has a central regulatory role because it controls production and secretion of the two gonadotrophins, ...

Unexplained or idiopathic pituitary stalk thickening (PST) often represents a diagnostic conundrum in children and young people. PST can be the first sign of an occult malignancy (>40% of the known aetiologies are neoplastic, particularly when associated with AVP-deficiency), but it can also reflect inflammatory, autoimmune or infectious processes, as well as congenital defects. What is perceived at PST on neuroimaging could even simply represent the upper end of the physio...