hrp0092fc13.1 | Adrenals and HP Axis | ESPE2019

Peptide MC2R Antagonists as a New Potential Therapeutic Approach for Congenital Adrenal Hyperplasia

Schubert Tina , Nicke Lennart , Schanze André , Reisch Nicole , Geyer Armin , Koehler Katrin , Huebner Angela

Current hormone substitution therapy of patients with congenital adrenal hyperplasia (CAH) is suboptimal and cannot mimic physiological daily rhythms of hormone secretion. As supra-physiological corticoid doses are necessary to avoid adrenal androgen excess, patients show substantially increased comorbidities such as hyperglycemia, arterial hypertension, reduced growth and osteoporosis. Moreover plasma ACTH is often inadequately suppressed, resulting in undesired excess adrena...

hrp0092rfc2.2 | Bone, Growth Plate and Mineral Metabolism Session 1 | ESPE2019

Does the Treatment with Recombinant Human Growth Hormone Improve Final Height in Patients Affected by X-Linked Hypophosphatemia?

André Julia , Zhukouskaya Volha V. , Rothenbuhler Anya , Lambert Anne-Sophie , Salles Jean-Pierre , Mignot Brigitte , Linglart Agnès

Background/Aim: 25 to 40% of children with well-controlled X-linked hypophosphatemia (XLH) show linear growth failure, despite optimal conventional treatment (oral phosphate supplementation and active forms of vitamin D) with final height -2 SDS. Recombinant human growth hormone (rhGH) may be an adjuvant treatment of the growth retardation in these patients. Therefore, the main objective of this study was to describe how rhGH treatment improves final heigh...

hrp0092rfc13.4 | Adrenals and HP Axis | ESPE2019

Loss-Of-Function NNT Mutations Impair Antioxidants Mechanisms and Decreases Cortisol Secretion in Patients with Famililar Glucocorticoid Deficieny

Faccioli Bodoni Aline , Coeli-Lacchini Fernanda , Gebenlian Juliana , Sobral Lays , Moreira Ayrton , Elias Lucila , Silva Wilson , de Catro Margaret , Leopoldino Andréia , Antonini Sonir

Background: The mitochondrial enzyme nicotinamide nucleotide transidrogenase (NNT) is essential in the antioxidant defense mechanisms and appears to be essential to the stages of adrenal steroidogenesis that occur inside the mitochondria.Aim: To characterize how mutations in NNT gene impair adrenal steroidogenesis resulting in familial glucocorticoid deficiency (FGD).Methods: Genom...

hrp0092p1-85 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Bone Mineral Density is Normal in Prepubertal Patients with Turner Syndrome when Corrected by Height/age

Dallago Renata Thomazini , Santos Allan Oliveira , Marmo Denise Barbieri , Guerra-Júnior Gil , Morcillo André Moreno , Lemos-Marini Sofia Helena Valente

Introduction: Turner's syndrome (TS) is associated with several manifestations the most frequent being short stature and hypogonadism. Some authors (Nadeem, 2012; Bakalov, 2008) reported that individuals with TS have increased risk of fractures, but the etiology and mechanism of bone fragility have not been yet fully elucidated and may be exacerbated by hormonal factors (Cintron, 2017; Soucek, 2015). Bone densitometry (BD) through the emission of double en...

hrp0092p1-110 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

References for Testicular Volume Measured by Ultrasound and for Pubic Hair in 6-16 Year-Old Norwegian Boys

Oehme Ninnie B. , Roelants Mathieu , Bruserud Ingvild S. , Madsen André , Eide Geir Egil , Bjerknes Robert , Rosendahl Karen , Júlíusson Pétur B.

Objective: Recent studies have suggested earlier onset of pubertal development in boys. As assessment with orchidometer tends to overestimate true testicular volume (TV), and measurements based on ultrasound (US) have been proposed as a more reliable method, we present US based references in 6-16 year-old Norwegian boys. Our results are compared with data from Europe and the United States (U.S.) in order to establish evidence for an ongoing secular trend in ma...

hrp0092p1-258 | Pituitary, Neuroendocrinology and Puberty (1) | ESPE2019

Novel Pubertal References for Girls Using Ultrasound to Stage Breast Development. The Bergen Growth Study 2

Bruserud Ingvid S. , Roelants Mathieu , Oehme Ninnie HB , Madsen André , Eide Geir Egil , Rosendahl Karen , Júlíusson Pétur B.

Background: Using ultrasound to examine the glandular breast tissue is a promising method for staging pubertal breast development. However, breast ultrasound for this purpose has not been explored in a large sample of healthy girls in different developmental stages, and normative data have been unavailable.Objective: To present novel pubertal references for breast ultrasound stages, Tanner breast (B) and pubic hair (PH) ...

hrp0092p1-267 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Endocrine Profiling and Association with Ultrasound Measured Testicular Volume and Biometrics in a Cohort of Norwegian Boys

Madsen André , Oehme Ninnie , Bruserud Ingvild , Roelants Mathieu , Sagen Jørn , Mellgren Gunnar , Júlíusson Pétur

Introduction: Male puberty is initiated by endocrine signaling in the hypothalamic-pituitary axis whereby follicle-stimulating hormone (FSH) and luteinizing hormone (LH) enable testicular maturation and synthesis of testosterone. Recent publications have eluded to overnutrition and obesity as relevant factors that may accelerate the timing of puberty. Attainment of testicular volume (TV) 4 ml measured by Prader orchidometer remains the definition of male puber...

hrp0092p1-57 | Fat, Metabolism and Obesity | ESPE2019

Put Your Money Where Your Mouth is: Preliminary Evidence that Oral Microbiota Diversity may Shape Later Cardiometabolic Health in Children

Henderson Mélanie , Nicolau Belinda , Van Hulst Andraea , Simoneau Gabrielle , Barnett Tracie A. , Drapeau Vicky , Tremblay Angelo , Mathieu Marie-Ève , Paradis Gilles , Zappitelli Michael , Varin Thibaut , Marette André

Background: Emerging evidence suggests a link between the intestinal microbiota and cardiometabolic outcomes in both children and adults. The oral microbiota is less studied, and the association between the oral microbiota and cardiometabolic health in childhood remains largely unknown.Objective: To explore the associations between oral microbiota diversity measured at 8-10 yr and cardiometabolic health in childhood and ...

hrp0092p1-197 | Fat, Metabolism and Obesity (1) | ESPE2019

You are What You Eat: Preliminary Evidence of Associations Between Dietary Habits and Oral Microbiota Composition in Early Childhood

Henderson Mélanie , Nicolau Belinda , Van Hulst Andraea , Simoneau Gabrielle , Barnett Tracie A. , Drapeau Vicky , Tremblay Angelo , Mathieu Marie-Eve , Paradis Gilles , Zappitelli Michael , Varin Thibaut , Marette André

Background: Oral microbiota composition and diversity differ between obese and non-obese individuals. However, the associations between lifestyle habits (implicated in the pathogenesis of obesity) and the oral microbiota remain uncertain, particularly among children.Objective: To explore the associations between oral microbiota diversity and lifestyle habits among 8-10 year-old children.Met...