hrp0095p1-261 | Diabetes and Insulin | ESPE2022

Parental stress in children with type 1 diabetes from different socioeconomic backgrounds

Levy-Khademi Floris , Heifetz Eliyahu , Avnon-Ziv Carmit , Auerbach Adi , Birnbaum Hanna

Background: Type 1 diabetes is one of the most common chronic diseases in childhood. Parents of children with type 1 diabetes are significantly involved in the treatment, rendering them vulnerable to parental stress. Psychological difficulties experienced by the parents may have adverse effects on disease management and the child's psychological and somatic health.Objectives: To assess parental stress and factors in...

hrp0092p3-211 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Peculiarities of Clinical Options for Delaying Sexual Aging in Boys-Adolescents

Kosovtsova Hanna

Delayed puberty (DP) in boys is considered the most common hypoandrogenia of puberty. It should be noted that DP adversely affects physical development, body formation and the health status of adolescents. The heterogeneity of the population of adolescents with DP has led to a differentiated approach and the allocation of the following three clinical options (CO) of DP: 1 - DP, accompanied by growth retardation; 2 - DP without significant deviations in physical development; 3 ...

hrp0095fc2.6 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Pseudohypoparathyroidism Type 1A (PHP1A): Growth patterns under growth hormone therapy for short stature

Ertl Diana-Alexandra , Mantovani Giovanna , Perez de Nanclares Guiomar , Gleiss Andreas , Hanna Patrick , Marta Elli Francesca , Pereda Arrate , Rothenbuhler Anya , Audrain Christelle , Berkenou Jugurtha , Linglart Agnes

Background: Pseudohypoparathyroidism 1A, newly classified as inactivating PTH/PTHrP signaling disorder type 2 (iPPSD2), is defined by resistance to parathyroid hormone, short stature and early-onset obesity. Short stature is caused by skeletal dysplasia and additionally, in some cases, also by the coexistence of growth hormone deficiency, as other hormonal resistances might be present (e.g. thyroid-stimulating hormone, growth hormone releasing hormone (GHRH), ...

hrp0089p1-p218 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Primary Gonadal Dysgenesis in Male 46,XY Patients with NR5A1 Variants Predominantly Affects Sertoli Cell Function

Hoppmann Julia , Werner Ralf , Lunstedt Ralf , Birnbaum Wiebke , Schwab Otfried , Marshall Louise , Wunsch Lutz , Hiort Olaf

Background: Steroidogenic factor 1 (encoded by the NR5A1 gene) is a transcriptional regulator of genes involved in gonadal development and steroidogenesis. Mutations in NR5A1 are associated with a wide phenotypic spectrum in 46,XY individuals ranging from partial/complete gonadal dysgenesis or anorchia, ambiguous genitalia, hypospadias, to infertility. However, little is known about the longitudinal course of endocrine markers for Sertoli and Leydig cell func...

hrp0095p2-126 | Fat, Metabolism and Obesity | ESPE2022

Vitamin D, OPG in Obese Children

Mikhno Hanna , Solntsava Anzhalika

Objective: Determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 210 children in the University Hospital (Minsk) from 2021 to 2022 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) ...

hrp0084p1-136 | Turner & Puberty | ESPE2015

The Eap1 Promoter is Differentially Methylated at the Onset of Puberty in Normal Weight and Obese Female Rats

Moeller Hanna , Heger Sabine

Background: Mammalian puberty is initiated by the pulsatile release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Enhanced at puberty (Eap) 1 is a transcription factor within this regulatory network integrating exogenous and endogenous informations, e.g. weight. Recent studies indicate an epigenetic regulation of the pubertal process.Objective and hypotheses: This study investigates if overweight modifies epigenetic marks i...

hrp0094p2-194 | Fat, metabolism and obesity | ESPE2021

Vitamin D deficiency in obese children

Mikhno Hanna , Solntsava Anzhalika ,

Objective: determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2019 to 2021 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 159...

hrp0097p2-70 | Fat, Metabolism and Obesity | ESPE2023

Association of osteoprotegerin and metabolic status in obese children.

Mikhno Hanna , Solntsava Anzhalika

Objective: determination of changes in metabolic status and osteoprotegerin (OPG) concentrations in obese children.Methods: We examined 220 children in the University Hospital (Minsk) from 2022 to 2023 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of OPG, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO)...

hrp0092p2-111 | Fat, Metabolism and Obesity | ESPE2019

Osteoprotegerin and Metabolic Status in Children with Obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: determination of changes in metabolic status and osteoprotegerin concentrations in obese children.Methods: We examined 120 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, insulin we...

hrp0089p3-p137 | Fat, Metabolism and Obesity P3 | ESPE2018

The Level of the Vitamin D and Metabolic Status in Children with Obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: Determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 212 children in the University Hospital (Minsk) from 2016 to 2018 years. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin, uric acid were determined. All children were divided into 2 groups: group 1 children with morbid obesity – 140 patients (90 boys(B)...