hrp0098pl7 | Fat & Bone; where are we now? | ESPE2024

Bone and Fat: Where are We Now?

Rosen Clifford

Marrow fat (BMAT) is an essential component of the bone marrow niche and plays a critical role during adaptive metabolism and stress responses. BMAT increases from birth and reaches a peak during adolescence and then is maintained until late in life when it increases again. Previous studies demonstrated a negative relationship between bone mineral density and BMAT; however those were predominantly cross sectional studies. New mouse models and inbred strains have provided novel...

hrp0095p1-180 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

The lifetime cost of reproductive potential – who spends the most?

Fuchs Shai , Goldenfeld Miki , Dviri Michal , Librach Clifford , Baum Micha

Objectives: To determine who spends more energy over a lifetime on maintaining their reproductive potential: men or women?Design: As a model and energetic equivalent, we set the mass of gametes supported over time from birth until exhaustion of fertility. We calculated gender-specific dynamics of gamete pool mass over time. To this purpose we collated data from existing literature, accounting for gamete volume over stage...

hrp0086p2-p82 | Adrenal P2 | ESPE2016

A Novel Mutation of HSD3beta2 Presenting as Hypospadias with Salt-wasting in a Male Infant

Buchanan C.R. , Kalitsi J. , Ghataore L. , Taylor N.F. , Clifford-Mobley O. , Rumsby G. , Kapoor R.R.

Background: HSD3B2 is a rare cause of autosomal recessive primary adrenal insufficiency, potentially associated with under virilisation of XY males and virilisation of XX females. We present a case of a male infant presenting at term with ambiguous genitalia (DSD) with underlying diagnosis confirmed biochemically and genetically with a novel mutation of HSD3beta2.Objective: Case report.Patients and methods: Baby was born as FTND wi...

hrp0082p1-d3-101 | Sex Development | ESPE2014

Subjective Need for Psychological Support in Parents of Children with dsd: Results from the German Clinical Evaluation Study

Bennecke Elena , Werner-Rosen Knut , Krude Heiko , Thyen Ute , Lux Anke , Kleinemeier Eva , Jurgensen Martina , Kohler Birgit , Group DSD Network Working

Introduction: The diagnosis of a disorder/difference of sexual development (dsd) is an exceptional psychosocial situation. As the diagnosis is often made in childhood, the parents are the primary communication partners. In some cases, the impossibility of immediate sex determination of the child can be a traumatic experience with a negative impact on the relationship between the parents and the child, the couple and members of the entire family. It has been recommended by the ...