hrp0098p1-111 | Adrenals and HPA Axis 2 | ESPE2024

Investigating Changes in Plasma Aldosterone Concentrations Following ACTH Stimulation in Healthy Individuals: A Systematic Review and Meta-Analysis on the Influence of ACTH on Aldosterone Secretion

Stathori Galateia , Alexakis Dimitrios , Panagiotis Chrousos George , Paltoglou George

Adrenocorticotropic hormone (ACTH) in addition to renin-angiotensin- aldosterone axis is a potent aldosterone stimulator, suggesting a potential contribution in conditions associated with increased ACTH concentrations. This review aims to systematically review and synthesize the scientific evidence of alterations of plasma aldosterone concentrations in response to ACTH stimulation during the cosyntropin (Synacthen) test and define the range of aldosterone response. A systemati...

hrp0095p1-30 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Vitamin D may facilitate Clock/Bmal1-DNA interactions in a Vitamin D receptor-independent fashion

Nicolaides Nicolas , Papakonstantinou Eleni , Vlachakis Dimitrios , Chrousos George

Background: The Clock/Bmal1 transcription factor heterodimer regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes. 1,25 Dihydroxy Vitamin D (Vitamin D), a sterol hormone that is activated by exposure to sunlight, plays a fundamental role in maintaining calcium and phosphorus homeostasis. Recent evidence suggests that the nuclear vi...

hrp0092fc13.6 | Adrenals and HP Axis | ESPE2019

Insights Into the Role of Cortisol in the Formation of the Clock/Bmal1 Complex and its Interaction with dsDNA, via Molecular Dynamics Simulations

Nicolaides Nicolas , Raftopoulou Sofia , Kino Tomoshige , Vlachakis Dimitrios , Chrousos George

Background: The circadian rhythm-generating peripheral Clock/Bmal1 heterodimer complex regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes.Objective and Hypotheses: To investigate the potential role of elevated cortisol in Clock/Bmal1 heterodimer complex-generated circadian biorhythms, both ...

hrp0082p1-d3-167 | Growth (2) | ESPE2014

Aromatase Inhibitors in Girls: Anastrazole Combined to an LHRH Analogue is a Safe and Effective Strategy in Girls with Early or Precocious Puberty with Compromised Growth Potential

Papadimitriou Dimitrios T , Dermitzaki Eleni , Papaevangelou Vassiliki , Papadimitriou Anastasios

Background: Third generation aromatase inhibitors have been used to increase predicted adult height (PAH) in boys but in girls only in McCune–Albright syndrome.Objective and hypotheses: We overcame the theoretical concern of secondary hyperandrogenism by combining anastrazole to an LHRH analogue in a 6-year prospective study to test whether the combination therapy could significantly improve PAH compared to inhibition of puberty alone.<p class="...

hrp0089p1-p127 | Fat, Metabolism and Obesity P1 | ESPE2018

PCSK9 and Lp(a) Levels of Children Born after Assisted Reproduction Technologies

Kosteria Ioanna , Terentes-Printzios Dimitrios , Koutagiar Iosif , Vlachopoulos Charalambos , Gkourogianni Alexandra , Sakka Sophia , Skoumas Ioannis , Miliou Antigoni , Papassotiriou Ioannis , Loutradis Dimitrios , Chrousos George P , Tousoulis Dimitrios , Kanaka-Gantenbein Christina

Background/Aims: Since the introduction of Assisted Reproduction Technologies (ART), including classic In Vitro Fertilization (IVF) and Intacytoplasmic Sperm Injection (ICSI), in clinical practice, several studies have addressed concerns regarding the long-term health of the offspring, revealing indications of an adverse cardiometabolic outcome. Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating level is significantly associated with an increased risk of cardiov...

hrp0095p1-238 | Diabetes and Insulin | ESPE2022

Faster-acting insulin Fiasp vs insulin Novorapid in type 1 diabetes children and adolescents with sensor-augmented pump therapy

Xatzipsalti Maria , Triantafillidou Antigoni , Kourousi Giannoula , Patouni Konstantina , Bourousis Evangelos , Kassari Elisavet , Delis Dimitrios , Vazeou Andriani

Introduction: Rapid-acting insulin analogues have been developed to mimic more closely the physiological action of endogenous insulin. However, they still have a delayed onset of action and a longer duration compares to endogenous insulin. Therefore, newer insulin analogues have been developed with a faster onset and a shorter duration of action.Aim: To evaluate the efficacy of rapid-acting insulin analogues (Novorapid) ...

hrp0095p1-270 | Fat, Metabolism and Obesity | ESPE2022

Homology modelling analysis provides insight into ADCY3, a candidate obesity gene

Toumba Meropi , Fanis Pavlos , Neocleous Vassos , Vlachakis Dimitrios , Phylactou Leonidas , Skordis Nicos , Mantzoros Christos , Pantelidou Maria

Background: In an effort to better understand the molecular basis of obesity, studies focus on genetic loci mapping to the leptin–melanocortin pathway, one of the key mechanisms for controlling food intake and body weight. Adenylate cyclase 3 (ADCY3) is a key genetic candidate as it seems to have an essential role at primary neuronal cilia in regulating body weight. We have previously reported the novel probably pathogenic ADCY3</em...

hrp0092p1-16 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Normocalcemic Hyperparathyroidism in Children

Papadimitriou Dimitrios T. , Dermitzaki Eleni , Kleanthous Kleanthis , Papadimitriou Anastasios , Mastorakos George

Normocalcemic primary hyperparathyroidism (NPHPT) has been recognized as a variant of primary hyperparathyroidism (PHPT) and it is characterized by elevated PTH with persistently normal concentrations of albumin-adjusted total and ionized calcium. It is related to increased risk in development of osteopenia/osteoporosis as well of parathyroid adenoma and hypercalcemia/hypercalciuria. In order to identify biochemical disorders of PTH in normocalcemic children we performed in al...

hrp0092p3-301 | Late Breaking Abstracts | ESPE2019

A novel heterozygous mutation in the SLC5A2 gene causing mild failure to thrive and subclinical hypoglycemia in a 2-year old girl

Dermitzaki Eleni , Manolakos Emmanouil , Filiousi Fotini , Kleanthous Kleanthis , Papadimitriou Dimitrios T.

Patients: A 2-year old girl was referred due to glucosuria 1874 mg/dl. Fasting blood sugar was 71 mg/dl and HbA1c 4.8%. Examination of her growth charts revealed mild failure to thrive, since 15 months of age, as far as weight gain and height velocity. We used Flash technology (FreeStyle Libre) to identify hypoglycemic episodes. In 9 days, 8% of the time was < 70 mg/dl, with 11 hypoglycemic events: mean duration 94 min, lowest 52 mg/dl.<p class...

hrp0089rfc9.4 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2018

REplacement of MAle mini-Puberty in Neonates and Children with Micropenis and Cryptorchidism due to Hypogonadotropic Hypogonadism: Results of the ‘REMAP’ Study ISRCTN13007297

Papadimitriou Dimitrios T , Chrysis Dionysios , Nyktari Georgia , Zoupanos George , Liakou Eleni , Papadimitriou Anastasios , Mastorakos George

Background: Hormonal replacement in boys with congenital Hypogonadotrophic Hypogonadism (HH) as well as hormonal repair of bilateral cryptorchidism and micropenis remain a challenge in pediatric endocrinology.Methods: In the «REMAP» study ISRCTN13007297 eight neonates and infants, all with bilateral cryptorchidism in intra-abdominal position and micropenis (≤2 cm), with absence of neonatal male-mini puberty were treated for 3 months with ...