hrp0082p3-d1-764 | Fat Metabolism & Obesity | ESPE2014

Prevalence of Metabolic Syndrome and Insulin Resistance Among Aged 3–9 Children

Hatipoglu Nihal , Kurtoglu Selim , Mazicioglu Mumtaz , Okdermir Deniz , Gul Ulku

Background: Metabolic syndrome (MS) is increasingly reported in obese children. So far, MS evaluations were performed for children at the age of 10 and over.Objective and hypotheses: Our aim is to evaluate the prevalence of MS and insulin resistance (IR) in obese children between 3 and 9 years old according to modifying National Cholesterol Education Program Adult Treatment Panel-III (NCEP-III) and International Diabetes Federation (IDF) criteria.<p ...

hrp0086p2-p55 | Adrenal P2 | ESPE2016

The Treatment of a Functional Adrenocortical Cancer with Mitotane

Kurtoglu Selim , Hatipoglu Nihal , Gul Ulku , Tatlı Zeynep Uzan , Akın Leyla , Kendirci Mustafa

Introduction: In the pediatric age group, the incidence of the adrenocortical cancer (ACC) is 0.2%. The effective treatment is surgical resection. The only medical option is mitotane but it has negative effects on steroidogenesis. The difficulty in the management of mitotane therapy is discussed in this case.Case report: An 1110/12 years-old boy was referred with A 5 cm diameter solid-hypoecoic mass observed by sonography in the left surrenal ...

hrp0086p1-p198 | Diabetes P1 | ESPE2016

Neonatal Siabetes, Gallbladder Agenesis and Cholestatic Giant Cell Hepatitis: A Novel Homozygote Mutation in PDX-1 Gene

Ozturk Mehmet Adnan , Ozdemir Ahmet , Gul Ulku , Hatipoglu Nihal , Korkut Sabriye , Ceylan Mahir , Kurtoglu Selim

Background: It is known that PDX-1 gene mutation is related to neonatal diabetes, pancreas agenesis and intrauterine growth retardation. Here the aim was to present a novel defined mutation in PDX-1 gene in case born with IUGR, diagnosed with neonatal diabetes and in which exocrine pancreas deficiency and gallbladder agenesis were detected.Case presentation: Blood glucose was measured as 185 mg/dl in the first hour after birth and insulin infusion was gi...

hrp0086p2-p783 | Pituitary and Neuroendocrinology P2 | ESPE2016

Basal Levels of FSH and LH can be Helpfull in Diagnosis of Puberty Precocious?

Gul Ulku , Samur Bahadir , Tatlı Zeynep Uzan , Hatipoglu Nihal , Kendirci Mustafa , Kurtoglu Selim

Background: Luteinizing hormone stimulating hormone (LHRH) test is the gold standard test in the diagnosis of puberty precocıous (PP). The basal levels of FSH (follicular stimulating hormone) and LH (luteinizing hormone) cannot be always reliable.Objective and hypotheses: To investigate the relation between the LHRH test and basal levels of FSH and LH.Method: Girls with puberty started before the age 8 are investigated. Eighty...

hrp0082p3-d2-745 | Diabetes (3) | ESPE2014

A Case of Type 2 Diabetes Associated with Ichthyosis: Chanarin–Dorfman Syndrome

Hatipoglu Nihal , Okdemir Deniz , Akin Leyla , Gokay Songul , Kardas Fatih , Kendirci Mustafa , Gul Ulku , Kurtoglu Selim

Background: Chanarin–Dorfman syndrome is a rare autosomal recessively inherited neutral lipid disorder which is characterized by congenital ichthyosis and multiple system involvement. It is diagnosed by visualization of lipid vacuoles in neutrophiles (Jordon anomaly) in suspicious cases. This syndrome can be associated with type 2 diabetes.Aim: We wished to remind this very rare disease in differential diagnosis of ichthyosis associating with diabet...

hrp0082p3-d3-750 | Diabetes (4) | ESPE2014

A Case of Type 1 Diabetes Associated with Cerebellar Ataxia: Stiff-Person Syndrome

Kurtoglu Selim , Okdemir Deniz , Hatipoglu Nihal , Akin Leyla , Gul Ulku , Canpolat Mehmet , Kendirci Mustafa

Background: Stiff-person syndrome (SPS) is a rare disorder which is characterized by muscle rigidity, spasm and cerebellar abnormalities. The etiology is not clarified yet. 80% of cases are caused by an autoantibody against GAD that inhibits synthesis of GABA. Other autoimmune diseases such as type 1 diabetes mellitus and thyroiditis are often associated.Aim: To underline the importance of considering SPS in differential diagnosis of patients with type 1...

hrp0082p3-d2-777 | Fat Metabolism &amp; Obesity (1) | ESPE2014

The Interaction of Exophtalmos with Obesity in Turkish Children and Adolescents

Cicek Betul , Ozturk Ahmet , Mazicioglu Mumtaz , Kurtoglu Selim , Kara Tuncay , Hatipoglu Nihal

Background: Many clinicians are aware of the systemic complications of obesity, however there are few studies on the effect of the ocular manifestations of obesity. The ocular complications of obesity include diabetic retinopathy, high intraocular pressure, cataracts, macular degeneration, floppy lid syndrome, pseudotumor cerebri, and exophthalmos. All of these complications can have serious consequences to the individual’s ocular health and visual well-being.<p class...

hrp0084p2-503 | Perinatal | ESPE2015

Serum Fetuin-a Level for Diagnosis Hepatic Steatosis in Children with Type 1 Diabetes Mellitus

Kurtoglu Selim , Dogan Murat , Hatipoglu Nihal , Muhtaroglu Sebahattin , Doganay Selim , Gul Ulku , Elmali Ferhan

Backgound: Type 1 diabetes mellitus (T1DM) is one of the chronic disease frequently encountered in childhood and the non-alcoholic fatty liver disease is one of the uncommon complications in the management of these patients.Objective and hypotheses: In this study, we aimed to investigate the relationship between serum fetuin-A levels which a negative acute phase reactant and the non-alcoholic fatty liver disease in T1 diabetic patients.<p class="abst...

hrp0084p3-666 | Bone | ESPE2015

Parathyroid Adenoma Should be Considered in the Management of Hypophosphataemic Rickets

Okdemir Deniz , Gul Ulku , Akin Leyla , Hatipoglu Nihal , Kendirci Mustafa , Kurtoglu Selim

Background: X-linked dominant hypophosphatemic rickets (XLHR) is a rare hereditary metabolic bone disorder. Calcitriol and phosphates are used for the treatment and hyperparathyroidism rarely occurs as a complication. We report a case of XLHR who developed autonomous parathyroid hyperfunction during treatment and underwent surgery for that.Case: A male patient was presented with short stature and bone deformities at age 11 months and diagnosed with XLHR ...

hrp0092p1-244 | Multisystem Endocrine Disorders | ESPE2019

Two Different Endocrine Cancer, One Disease; DICER-1 Mutation

Tatli Zeynep Uzan , Direk Gül , Özcan Alper , Hatipoglu Nihal , Kendirci Mustafa , Kurtoglu Selim

Autosomal dominant DICER1 mutations are among the causes of early-onset familial cancer. DICER1 mutation has been shown in pleuropulmonary blastomas as well as ovarian tumors, thyroid, parathyroid, pituitary, adrenocortical and testicular tumors. It is important to be aware of the risk for the development of other cancers in the follow-up of these cases.Cases: Case-1: Previously known to be healthy 8,5-year-old girl presented with compla...