hrp0094p1-106 | Adrenal B | ESPE2021

Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel Proteomic Signature

Nicolaides Nicolas C. , Makridakis Manousos , Stroggilos Rafael , Koniari Eleni , Papageorgiou Ifigeneia , Sertedaki Amalia , Zoidakis Jerome , Charmandari Evangelia ,

Background: Tissue sensitivity to glucocorticoids is characterized by significant inter-individual variation in terms of therapeutic response and susceptibility to several stress-related disorders. Proteomics approaches, combined with appropriate bioinformatics analysis, offer a comprehensive description of molecular phenotypes with clear links to human disease pathophysiology.Objective and Hypotheses: To investigate the usefulness of pl...

hrp0095p1-259 | Diabetes and Insulin | ESPE2022

Tear Proteomics in Children and Adolescents with Type 1 Diabetes Mellitus and Correlation with Cognitive Function Levels

Nicolaides Nicolas , Makridakis Manousos , Kitani Rosa-Anna , Letsou Konstantina , Kressou Evangelia , Angelopoulou Eleni , Vasilakis Ioannis-Anargyros , Kosteria Ioanna , Mantzou Aimilia , Papassotiriou Ioannis , Varvogli Liza , Zoidakis Jerome , Kanaka-Gantenbein Christina

Background: Several studies have shown that type 1 diabetes mellitus (T1DM) may contribute to the early onset or acceleration of cognitive impairment (intelligence, psychomotor efficiency, information management speed, visual attention, visual perception and cognitive flexibility). Tear proteomics seems to provide useful information for understanding the molecular mechanisms of various ocular and systemic diseases.Objective and H...

hrp0094p2-122 | Diabetes and insulin | ESPE2021

Parental insulin resistance is associated with unhealthy lifestyle behaviours independently of body mass index in children: The Feel4Diabetes study

Gonzalez-Gil Esther M. , Gimenez-Legarre Natalia , Cardon Greet , Mavrogianni Christina , Kivela Jemina , Iotova Violeta , Tankova Tsvetalina , Imre Rurik , Liatis Stavros , Makrilakis Konstantinos , Schwarz Peter , Timpel Patrick , Dupont Elisabeth , Couck Pedro , Manios Yannis , Moreno Luis ,

Introduction and aim: Parental health is associated with children’s health and lifestyles. Thus, the aim of the present study was to assess lifestyle behaviours of children from parents with insulin resistance (IR) and at risk of type 2 diabetes.Methods: 2117 European parents from six countries included in the Feel4Diabetes-study measured in 2015 and identified as being at risk for diabetes with the FINDRISC questio...