ESPE Abstracts

Exercise-related reproductive dysfunction appears to be multifactorial in origin and remains a diagnosis of exclusion. The main factors etiologically correlated with menstrual disturbances in athletes are body composition, stress (physical exercise and psychological stress), energy balance (energy availability), diet, training methods (sports character) and reproductive maturity. Recent data highlight the endocrine role of the adipose tissue in the regulation of metabolism and...

Background: Glucocorticoids regulate a broad spectrum of physiologic functions essential for life and exert their actions through their ubiquitously expressed glucocorticoid receptor (GR). The GR interacts with several molecules, including the non-coding RNA growth arrest-specific 5 (Gas5), which decreases the transcriptional activity of the GR by preventing its binding to DNA, and reduces tissue sensitivity to glucocorticoids.Objective and Hypotheses: T...