ESPE Abstracts

Background: Paediatric adrenocortical tumours (ACT) are rare and typically present with virilising symptoms and signs which can be similar to other virilising conditions such as congenital adrenal hyperplasia.Case description: We describe three cases of ACT diagnosed and managed at our institution over the past 10 years. The three girls presented with symptoms of virilisation. The mean interval between first symptoms and diagnosis was 19.6 months (rangin...

Primary adrenal insufficiency (PAI) is a rare but potentially life-threatening disease. When this happens very early in life, genetic causes should be considered. Here, we report a newborn who presented with hyperkalemia, hyponatriemia, hypoglycaemia and generalised hyperpigmentation, and was found to have primary adrenal insufficiency. This child also had concurrent issues of poor growth, sepsis and persistent pancytopenia. She was eventually diagnosed with MIRAGE syndrome (M...

Background: Data on prevalence and phenotypic distribution of dyslipidaemia in children with type 1 diabetes (T1D) is scarce. Studies have shown that lipid abnormality tracks from childhood to adulthood and contributes to atherosclerotic process, therefore initial assessment and follow-up is essential.Aims: To study the prevalence and phenotypic distribution of dyslipidaemia in children with T1D and compare with type 2 diabetes (T2D).<p class="abstex...

Background: Bone growth and mineralization during childhood are now recognized as important for bone health in adulthood, leading to renewed interest in identifying modifiable factors that impact bone mineral density (BMD) in childhood. Emerging data suggest that duration of breastfeeding may affect BMD in later childhood and adult life. However, such data are sparse and inconsistent.Objectives: This study examined the relationship betwe...

Introduction: Growth retardation is a frequent reason for consultation in pediatrics. The interrogation, the reconstruction of the evolution curve of the height and the weight, the clinical and paraclinical examination make it possible to orient the diagnosis. The etiologies are multiple, but most often the growth retardation is isolated, it is then said to be constitutional.Patients and methods: This is a prospective de...

Introduction: Short stature is a very common complication of juvenile idiopathic arthritis (JIA). Chronic inflammation, long-term corticosteroid therapy, hepatic impairment and malnutrition can reduce the biological effects of IGF-1 and GH. Growth hormone (GH) treatment may improve height growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). The aim of the study was to assess the response to growth hormone (GH) treatment in patients with...

Introduction: β-thalassemia is a chronic hereditary hemolytic anemia characterized by a defect in the synthesis of beta-globin chains, particularly common in the Mediterranean region, southern Asia, and the Middle East. Transfusion programs and chelation therapy have considerably extended the life expectancy of patients. This has led to an increase in the prevalence of complications related to iron overload, growth retardation is extremely common in polyt...

Introduction: Type 1 diabetes is frequently associated with other autoimmune diseases which can sometimes be integrated into autoimmune polyendocrinopathy. The objective of this study is to describe the frequency of autoimmune diseases in children with type 1 diabetes.Patients and Methods: A retrospective and descriptive study, involving 102 patients (54 males, 48 females) with type 1 diabetes followed in our department....

Introduction: Hyperthyroidism is a rare but potentially serious childhood disorder that, if left unchecked, can lead to a wide range of complications, including effects on growth and development. Medical history, physical examination and thyroid function tests help diagnose hyperthyroidism. Graves' disease is the most common cause of hyperthyroidism in children, accounting for over 95% of cases, and is caused by stimulating antibodies directed against the...

Introduction: Β-thalassemia is a chronic hereditary hemolytic anemia characterized by a defect of synthesis of beta-globin chains, particularly common in the Mediterranean region, southern Asia, and the Middle East. Chelation therapy significantly prolonged the life expectancy of patients. This has led to an increase in the prevalence of endocrine complications, linked to iron overload. Gonadal Dusfunction is a frequent complication in polytransfused beta...