hrp0098p1-30 | Diabetes and Insulin 2 | ESPE2024

The Impact of Sleep Quality and Metabolic Control in Children with Type 1 Diabetes: a Prospective Cohort Study

Al Khalifah Reem , Philby Mona , Al-Gadi Iman , Bashammakh Dina , Al Nassir Bayan , Al Ghamdi Sara , Taha Elawad Areej , Al Saif Hadeel , Alsunini Muna , Bahumayim Aya

Objectives: Characterizing the children’s and their caregivers’ sleep patterns and disturbances in children with Type 1 Diabetes Mellitus (T1DM) can improve diabetes management and outcomes. Therefore, we aimed to examine the associations between sleep quality in children with T1DM and metabolic outcomes namely, haemoglobin A1c, time in range.Method: This is a prospective cohort study included children with T...

hrp0097p2-259 | Late Breaking | ESPE2023

Saudi experience of long term treatment for Laron syndrome with IGF-1 injection over 22 years, cohort study

Binladen Amal , Al-ashwal Abdullah , Al-Fattani Areej

Background: Laron syndrome is an autosomal recessive disease caused by molecular defect in GH receptor gene. The patients have severe growth retardation and clinical features of GHD with low IGF-1, high basal GH and failed response to IGF-1 stimulation test. The only proved treatment is daily recombinant IGF-1 administration which showed improvement in linear growth.Aim: To describe the largest group of patients with lar...

hrp0097p1-221 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Celiac disease in a patient with Sclerosteosis: an association or just a co-incidence?

Abdelmeguid Yasmine , Riad Salma , Mokhtar Nada , Taha El-Hendawy Mahmoud

Sclerosteosis is a rare autosomal recessive disorder characterized by progressive skeletal overgrowth and increased bone density. Loss of function mutations of SOST gene, coding for sclerostin, are linked to sclerosteosis. Sclerostin plays a critical role inhibiting osteoblastic activity and preventing excessive bone formation by antagonizing the Wnt signaling pathway. Sclerosteosis patients are often tall and have excessive body weight due to high skeletal weight. To...

hrp0097p1-106 | GH and IGFs | ESPE2023

Growth Hormone (GH) Therapy in Children with short stature: A cross-sectional study of indication and treatment outcomes- 12-year single center experience

Al Jneibi Sara , Hammouri Marwa , Taha Fatima , Allami Zahraa , Weber Stefan , AlJubeh Jamal , Al Remeithi Sareea

Background: GH deficiency remains the main indication for GH therapy in children. GH therapy has subsequently been approved in the USA and Europe for other conditions resulting in short stature, including Turner Syndrome, being born small for gestational age with failure to attain normal growth, Prader-Willi Syndrome, chronic renal insufficiency, short stature homeobox-containing gene deficiency, and in the USA exclusively Noonan Syndrome and idiopathic short ...

hrp0092p3-2 | Adrenals and HPA Axis | ESPE2019

A Rare Cause of Primer Adrenal Insufficiency: NROB1 (DAX1) Mutation

Koprulu Ozge , Acar Sezer , Nalbantoglu Ozlem , Kirbiyik Ozgur , Arslan Gulcin , Ozkaya Beyhan , Ozdemir Taha Resid , Ozkan Behzat

Introduction: Congenital adrenal hypoplasia, a rare cause of childhood primer adrenal insufficiency, is caused by defects in transcription factors involved in the development of adrenal gland. One of them is the NROB1 (DAX1) gene, localized in Xp21.2. DAX1 mutations have been identified that cause X-linked adrenal hypoplasia congenita. Infants affected with X-linked adrenal hypoplasia congenita may present with salt-wasting, micropenis or cry...

hrp0092p1-245 | Multisystem Endocrine Disorders | ESPE2019

PTEN Hamartoma Tumor Syndrome (Overlap of Cowden syndrome and the Bannayan-Riley-Ruvalcaba Syndrome): Case Report

Manyas Hayrullah , Çatli Gönül , Eroglu Filibeli Berna , Ayranci Ilkay , Özdemir Taha Resid , Dündar Bumin Nuri

Introduction: PTEN Hamartoma Tumor Syndrome (PHTS) is a rare disease with dominant inheritance characterized by benign (hamartoma) and malignant tumors (breast, endometrium, thyroid). Mutations in the tumor suppressor gene phosphatase and tensin homologue (PTEN) gene are responsible for the etiology.Objective: In this case report, we present an 11-year-old male who was being monitored due to follicular thyroid cancer, an...

hrp0095p1-546 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Change of menarcheal age in schoolgirls living in Istanbul over the last 12 years

Guran Tulay , Alir Fahriye , Taha Arslan Yusuf , Molla Giasim , Sahin Berk , Emir Sayar Mehmet , Atay Zeynep , Helvacioglu Didem , Gurpinar Tosun Busra , Haliloglu Belma , Turan Serap , Hidiroglu Seyhan , Bereket Abdullah

Background: Menarche is the endpoint of a complex sequence of maturational events but is the unique marker of female puberty. Timing of menarche is a strongly heritable trait. However, secular trends suggest that lifestyle and/or environmental factors are important.Objective: To assess the trend in age at menarche (AAM) in Istanbul over the last 12 years, and compare the patterns according to socioeconomic status (SES), ...

hrp0092p2-12 | Adrenals and HPA Axis | ESPE2019

A Case of X-linked Adrenoleukodystrophy Presenting with Primary Adrenal Insufficiency and Normal VLCFA

Özkaya Beyhan , Acar Sezer , Özdemir Taha R. , Nalbantoglu Özlem , Köprülü Özge , Arslan Gülçin , Kutbay Yasar B. , Özkan Behzat

Introduction: X-linked adrenoleukodystrophy (X-ALD) is a rare autosomal recessive neurodegenerative disease caused by a mutation in the ABCD1 gene. Although its clinical presentation varies, X-ALD is generally characterized by progressive demyelination of the central nervous system, primer adrenal insufficiency, and elevated plasma very long-chain fatty acid (VLCFA) levels. Herein, we aimed to present a case of X-ALD with normal VLCFA caused by a path...