hrp0082p3-d2-744 | Diabetes (3) | ESPE2014

Nine-Year-Old Boy with Wolfram Syndrome: Case Report

Jakubowska Ewa , Michalak Justyna , Florys Bozena , Mlynarski Wojciech , Zmyslowska Agnieszka , Szadkowska Agnieszka , Luczynski Wlodzimierz , Olszewska-Glowinska Barbara , Bossowski Artur

Background: Wolfram syndrome is a rare progressive genetic neurodegenerative disorder connected with diabetes mellitus, diabetes insipidus, optic atrophy, deafness, neurologic, and endocrine abnormalities. Wolfram syndrome is inherited in autosomal recessive manner – due to mutation of the WFS1 gene which is located on chromosome 4.Objective and hypotheses: A 9-year-old boy, diagnosed with diabetes mellitus at the age of 5.5 years, was admitted to h...