ESPE Abstracts

Introduction: Growth hormone (GH) therapy in Turner Syndrome (TS) affects growth and glucose metabolism.Methods: Reviewed studies focused on GH therapy's impact on glucose metabolism in TS, selecting those with clear outcomes and sufficient sample sizes.Results: The effects of GH therapy on glucose metabolism in TS vary, with studies indicating both potential risks and benefit...

Background and aims: The impact of GnRH treatment on the timing of menarche, menstrual cycle status, and onset of menopause in girls with early/precocious puberty is of clinical interest. This study aims to provide insight into the effects of GnRH treatment on these aspects.Methods: A comprehensive literature search was conducted on PubMed for English articles published between 2010 and 2023. The focus was on studies, me...

Introduction: Managing pediatric hypothyroidism with thyroxine therapy is crucial for children's growth and development. This presents a synthesized overview of the relationship between thyroxine therapy and growth outcomes in children with congenital and acquired hypothyroidism.Methods: A literature review from 1987 to 2013 was conducted, selecting studies on thyroxine therapy's effects on linear growth, cogni...

Introduction: Subclinical hypothyroidism (SH) in children and adolescents is a condition characterized by elevated thyroid-stimulating hormone (TSH) levels with normal serum free thyroxine (T4). The clinical significance and natural course of SH remain subjects of debate, necessitating a review of the literature to guide management decisions.Methods: This review analyzed ten studies, encompassing both observational cohor...

Background: Thyroxine (T4) is critical in regulating growth and developmental processes. This review synthesizes 20 studies to examine thyroxine's effects on linear growth and development.Methods: A comprehensive review of the last two decades' research articles was conducted, selecting studies that examined thyroxine therapy on growth, development, and metabolic regulation in hypothyroid pediatric populations....

Objective: To synthesize evidence on subclinical hypothyroidism (SH) in children, focusing on prevalence, diagnostics, treatment, and progression.Methods: Review of 28 studies including observational cohorts and clinical trials on pediatric SH.Results: SH in children is associated with increased risks of obesity, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) due to ...

Introduction: This review aims to chronologically summarize MRI findings in children with GHD, correlating these changes with clinical characteristics and GH testing results, and IGF-1 levels.Methods: We reviewed MRI studies conducted from 1991 to 2024, focusing on structural and functional brain changes in children with GHD. Data were extracted from various studies and arranged chronologically.<st...

This review summarizes the prevalence and degree of functional brain changes detected by fMRI in Growth Hormone Deficiency (GHD) patients and their clinical associations in studies from 2019 to 2024Results: Author Year Prevalence of F...

Introduction: Idiopathic short stature (ISS) and growth hormone deficiency (GHD) are conditions that can result in various cognitive and behavioral abnormalities. Functional Magnetic Resonance Imaging (fMRI) is a valuable tool for investigating brain functional connectivity and maturity, offering insights into the neurological underpinnings of ISS and GHD. This review summarizes fMRI findings and their clinical associations, highlighting differences in brain m...

Introduction: This review summarizes the genetic findings in Growth Hormone Deficiency (GHD) versus Idiopathic Short Stature (ISS) and their effects on clinical, radiological, and laboratory outcomes.Methods: A literature review was conducted to identify studies reporting genetic findings related to GHD and ISS.Results: Genetic Findings in GHD: Mutations in GH-1, G...