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Designing monomeric dual or triple agonists based on glucagon-like peptide (GLP)-1 with glucagon, and/or glucose-dependent insulinotropic polypeptide (GIP) are promising novel approaches for anti-obesity drugs tackling different weight-regulatory pathways, albeit such developments continue to suffer from significant gastrointestinal illnesses. Our own studies have focused instead on the combination of GLP-1 receptor agonists (GLP-1RAs) with neuropeptide Y1- and Y2-receptor (Y1...

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hrp0095ha2 | The genetic landscape of children born small for gestational age with persistent short stature | ESPE2022

The genetic landscape of children born small for gestational age with persistent short stature

Toni Ledjona , Plachy Lukas , Dusatkova Petra , Anne Amaratunga Shenali , Elblova Lenka , Sumnik Zdenek , Kolouskova Stanislava , Snajderova Marta , Obermannova Barbora , Pruhova Stepanka , Lebl Jan

Background: Approximately 10% of children born small for gestational age (SGA) fail to catch-up nd remain short (SGA-SS). Although several mechanisms causing SGA-SS have been elucidated, the primary cause remains speculative in most cases.Aim: To decipher genetic causes of SGA-SS defined as birth length and/or birth weight <-2 SD for gestational age, and body height <-2.5 SD after the 3rd year of life within a larg...

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hrp0095fc1.1 | Thyroid | ESPE2022

Neonatal TSH screening for congenital hypothyroidism: before discharge or at home?

Boros Emese , Marcelis Lionel , Van Vliet Guy , Elilie Mawa Ongoth Farel , Heinrichs Claudine , Brachet Cecile

In Belgium, neonatal TSH screening for congenital hypothyroidism has been performed between day 3 and 5 of life since the late seventies. In January 2015, a policy of early discharge of healthy neonates was implemented so that the neonatal screening strategy had to be adapted. Between January 2015 and September 2019, dried blood spot sampling was mostly collected at home AFTER discharge at 72 h of life (Newborn Screening Strategy 1 (NBS1)). After October 2019, sampling was mos...

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hrp0095fc1.2 | Thyroid | ESPE2022

Comorbidity in congenital hypothyroidism - A nationwide population-based cohort study

Danner Emmi , Jääskeläinen Jarmo , Huopio Hanna , Niuro Laura , Niinikoski Harri , Kero Jukka , Sund Reijo

Aim of the study: The aim of this nationwide population-based register study was to investigate the incidence of congenital malformations, neonatal and chronic comorbidities, and the use of prescribed drugs in patients with primary congenital hypothyroidism (CH).Methods: The study cohort and matched controls were identified from national population-based registers in Finland (The Social Insurance Institution of Finland a...

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ESPE Abstracts

Development of Anorexigenic and Glucoregulatory Chimeric Peptides

The genetic landscape of children born small for gestational age with persistent short stature

Neonatal TSH screening for congenital hypothyroidism: before discharge or at home?

Comorbidity in congenital hypothyroidism - A nationwide population-based cohort study

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