hrp0098p3-128 | GH and IGFs | ESPE2024

Enhancing Diagnostic Accuracy in Growth Hormone Deficiency: A Comparative Analysis of Sex Steroid Priming in Pediatric Short Stature

Alyafei Fawzia , Soliman Ashraf , Qusad Mohamed , Hamed Noor , Alaaraj Nada , Ahmed Shayma , Elsayed Nagwa , Elsiddig Sohair

Introduction: This study presents a comparative analysis of the efficacy of sex steroid priming in enhancing growth hormone (GH) responses in short stature children undergoing GH stimulation tests.Methods: A randomized study encompassed a cohort of 40 children, divided into two groups: "With Priming" and "Without Priming". The primed group exhibited a higher peak GH response (6.53) compared to the non...

hrp0098p3-146 | Growth and Syndromes | ESPE2024

The Impact of Growth Hormone Therapy on Glucose Metabolism in Individuals with Turner Syndrome: A Comprehensive Review

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed shayma , Sabt Amal

Introduction: Growth hormone (GH) therapy in Turner Syndrome (TS) affects growth and glucose metabolism.Methods: Reviewed studies focused on GH therapy's impact on glucose metabolism in TS, selecting those with clear outcomes and sufficient sample sizes.Results: The effects of GH therapy on glucose metabolism in TS vary, with studies indicating both potential risks and benefit...

hrp0098p3-192 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Effect of GNRH treatment of girls with early/precocious puberty on menarche, menstrualcycle status, and onset of menopause.

Soliman Ashraf , Ahmed Shayma , sabt Amal , Alaaraj Nada , Hamed Noor , Khalil Ahmed , Alyafei Fawzia

Background and aims: The impact of GnRH treatment on the timing of menarche, menstrual cycle status, and onset of menopause in girls with early/precocious puberty is of clinical interest. This study aims to provide insight into the effects of GnRH treatment on these aspects.Methods: A comprehensive literature search was conducted on PubMed for English articles published between 2010 and 2023. The focus was on studies, me...

hrp0098p3-247 | Thyroid | ESPE2024

The Complex Relationship Between Thyroxine Therapy and Growth Outcomes in Pediatric Hypothyroidism

Soliman Ashraf , Alaaraj Nada , Sabt Amal , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Introduction: Managing pediatric hypothyroidism with thyroxine therapy is crucial for children's growth and development. This presents a synthesized overview of the relationship between thyroxine therapy and growth outcomes in children with congenital and acquired hypothyroidism.Methods: A literature review from 1987 to 2013 was conducted, selecting studies on thyroxine therapy's effects on linear growth, cogni...

hrp0098p3-248 | Thyroid | ESPE2024

The Natural Course of Subclinical Hypothyroidism in Children and Adolescents: A Comprehensive Review

Alaaraj Nada , Soliman Ashraf , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Adel Ashraf , Sabt Amal

Introduction: Subclinical hypothyroidism (SH) in children and adolescents is a condition characterized by elevated thyroid-stimulating hormone (TSH) levels with normal serum free thyroxine (T4). The clinical significance and natural course of SH remain subjects of debate, necessitating a review of the literature to guide management decisions.Methods: This review analyzed ten studies, encompassing both observational cohor...

hrp0098p3-250 | Thyroid | ESPE2024

Thyroxine's Role in Growth and Development: A Review of Clinical Effects

Alaaraj Nada , Soliman Ashraf , Sabt Amal , Adel Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Background: Thyroxine (T4) is critical in regulating growth and developmental processes. This review synthesizes 20 studies to examine thyroxine's effects on linear growth and development.Methods: A comprehensive review of the last two decades' research articles was conducted, selecting studies that examined thyroxine therapy on growth, development, and metabolic regulation in hypothyroid pediatric populations....

hrp0098p3-252 | Thyroid | ESPE2024

Impact of Subclinical Hypothyroidism on Pediatric Health: A Summary of Findings

Soliman Ashraf , Alaaraj Nada , Sabt Amal , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Objective: To synthesize evidence on subclinical hypothyroidism (SH) in children, focusing on prevalence, diagnostics, treatment, and progression.Methods: Review of 28 studies including observational cohorts and clinical trials on pediatric SH.Results: SH in children is associated with increased risks of obesity, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) due to ...

hrp0098p3-314 | Late Breaking | ESPE2024

MRI Structural and Functional Changes in Children with Growth Hormone Deficiency: A Chronological Review

Hamed Noor , Soliman Ashraf , Alyafei Fawzia , AlHemedi Noora , Alaaraj Nada , Ahmed Shayma , Elawwa Ahmed , Bedair Elsaid

Introduction: This review aims to chronologically summarize MRI findings in children with GHD, correlating these changes with clinical characteristics and GH testing results, and IGF-1 levels.Methods: We reviewed MRI studies conducted from 1991 to 2024, focusing on structural and functional brain changes in children with GHD. Data were extracted from various studies and arranged chronologically.<st...

hrp0098p3-315 | Late Breaking | ESPE2024

Prevalence and Clinical Associations of Functional Brain Changes in Children with Growth Hormone Deficiency: A Comprehensive Review

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , AlHemedi Noora , Elawwa Ahmed

This review summarizes the prevalence and degree of functional brain changes detected by fMRI in Growth Hormone Deficiency (GHD) patients and their clinical associations in studies from 2019 to 2024Results: Author Year Prevalence of F...

hrp0098p3-316 | Late Breaking | ESPE2024

Functional Magnetic Resonance Imaging (fMRI) Findings and Brain Maturity Index in Children with Idiopathic Short Stature and Growth Hormone Deficiency: A Comprehensive Review

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , AlHemedi Noora , Elawwa Ahmed , Noureldin Abbas

Introduction: Idiopathic short stature (ISS) and growth hormone deficiency (GHD) are conditions that can result in various cognitive and behavioral abnormalities. Functional Magnetic Resonance Imaging (fMRI) is a valuable tool for investigating brain functional connectivity and maturity, offering insights into the neurological underpinnings of ISS and GHD. This review summarizes fMRI findings and their clinical associations, highlighting differences in brain m...