hrp0098p2-379 | Late Breaking | ESPE2024

Hypothalamic obesity following craniopharyngioma surgery; what is the role of hypothalamic inflammation and gliosis?

Yurddas Doga , A.J. Nievelstein Rutger , Bison Brigitte , Hulsmann Sanne , Beckhaus Julia , L. Muller Hermann , M. van Santen Hanneke

Background: Childhood craniopharyngioma (cCP) poses significant risks of hypothalamic damage, leading to severe obesity in up to 75% of survivors. Despite hypothalamus-sparing surgical techniques, hypothalamic obesity remains a prevalent issue. We aim ed to fill a critical gap by exploring the presence of hypothalamic inflammation and gliosis following cCP surgery on MRI. In the future we will correlate our findings to subsequent hypothalamic dysfunction and o...