hrp0095p1-204 | Adrenals and HPA Axis | ESPE2022

Reduced cognitive function in children with classical 21-hydroxylase deficient congenital adrenal hyperplasia (21OHD-CAH).

Ladjouze Asmahane , Hamiche Nalia , Boulesnane Kamelia , Aboura Rawda , Bouhafs Nadjet , melzi souhila , Bouzerar Zair , Donaldson Malcolm

Background: In the absence of a national screening program for congenital adrenal hyperplasia (CAH), children are often diagnosed late, when unwell with salt-wasting crisis or hypoglycemic symptoms. In 21-hydroxylase deficient CAH (21OHD-CAH), girls usually present with a disorder of sex development (DSD) and are thus diagnosed earlier than boys who present with salt-wasting.Aim: To investigate the global intelligence of...

hrp0086p2-p386 | Gonads & DSD P2 | ESPE2016

High Prevalence of SGA in Patients with Disorders of Sexual Development, Especially Idiopathic 46,XY DSD

Ladjouze Asmahane , Taleb Ourida , Kedji Lila , Maoudj Abdeljalil , Berkouk Karima , Bensmina Manoubia , Aboura Rawda , Ouarezki Yasmine , Philibert Pascal , Anane Tahar , Sultan Charles , Laraba Abdenour

Background: Disorders of sex development (DSD) are a group of rare conditions characterized by variable discordance between chromosomal, gonadal and phenotypic sex. An association between smallness-for-gestational age (SGA) and DSD is already recognised, but few studies have investigated this in detail.Aim of study: To evaluate the prevalence of SGA, among patients with DSD and to establish a correlation with the different types and causes of DSD.<p ...

hrp0082p2-d2-547 | Puberty and Neuroendocrinology (1) | ESPE2014

The Triptorelin Test Compares Favourably with the GnRH Test in the Diagnosis of Central Precocious Puberty

Ladjouze Asmahane , Djermane Adel , Ouarezki Yasmine , Kedji Leila , Berkouk Karima , Abdeljalil Maoudj , Aboura Rawda , Bensmina Minoubia , Anane Tahar , Bouyoucef Salah Eddine , Laraba Abdenour

Background: The i.v. GnRH test remains the gold standard for the diagnosis of central precocious puberty (CPP). Unfortunately however, GnRH is expensive and is not available worldwide. GnRH analogues have been used as an alternative, but their place is not established, while very few studies have compared between the two tests.Objective: To compare the effects of GnRH and Triptorelin on gonadotrophin secretion in patients with sexual precocity and hence ...

hrp0097p1-406 | Adrenals and HPA Axis | ESPE2023

Congenital adrenal hyperplasia due to 11 β-hydroxylase deficiency: Clinical, Biochemical and Genetic characteristics

Ladjouze Asmahane , Mohammedi kahina , Demdoum Mohamed , Boulesnane Kamelia , Aboura Rawda , Melzi Souhila , Bouhafs Nadjet , Donaldson Malcolm , Janot Clément , Mallet Delphine , Bouzerar Zair , Roucher-Boulez Florence

Background: Congenital adrenal hyperplasia (CAH), resulting from mutations in CYP11B1 (gene encoding 11β-hydroxylase), is a rare autosomal recessive disorder due to an impairment of the last steroidogenesis step. Consequences are a decreased cortisol secretion, elevated plasma levels of ACTH, and accumulation of steroid precursors responsible of hyperandrogenism and hypertension. It is the second most frequent cause of CAH after 21-Hydroxylase de...

hrp0089p3-p005 | Adrenals and HPA Axis P3 | ESPE2018

Age at Diagnosis and Outcome in Maghreb patients with 21-hydroxylase Deficient Congenital Adrenal Hyperplasia; Urgent need for Newborn Screening

Ladjouze Asmahane , Yala Imane , Yahiaoui Manel , Zerguini Dounia , Tardy Veronique , Mohammedi Kahina , Taleb Ourida N , Kerkouche Soraya , Berkouk Karima , Bensmina Manoubia , Maoudj Abdeljlil , Aboura Rawda , Anane Tahar , Morel Yves , Bouzerar Zahir

Objectives: To examine age at presentation and outcome in children diagnosed with 21-hydroxylase deficient congenital adrenal hyperplasia (21-OHD CAH) in Algeria in the absence of a national neonatal screening program.Design: Retrospective analysis of patients followed in a single centre from 2007 to 2017. The diagnosis of CAH was established on clinical and biochemical grounds ± genetic analysis.Results: Of 168 patients (114F...