Abstract Search

hrp0086fc13.5 | Management of Obesity | ESPE2016

Effects of AZP-531, a First-in-Class Unacylated Ghrelin Analog, on Food-Related Behaviour in Prader-Willi Patients: A Multi-Center, Randomized, Placebo-Controlled Study

Allas Soraya , Caixas Assumpta , Poitou Christine , Coupaye Muriel , Thuilleaux Denise , Lorenzini Francoise , Diene Gwenaelle , Crino Antonino , Illouz Frederic , Grugni Graziano , Delale Thomas , Abribat Thierry , Tauber Maithe

Background: Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by hyperphagia and abnormal behaviours towards food for both of which no approved treatment is available. Elevated plasma acylated ghrelin (AG) documented at all ages in PWS suggest that the ghrelin system may contribute to the pathophysiology of hyperphagia. Administration of unacylated ghrelin and 8-amino acid analog AZP-531 prevents AG-induced food consumption in animals and improves glucose co...

0 shares

ESPE Abstracts

Effects of AZP-531, a First-in-Class Unacylated Ghrelin Analog, on Food-Related Behaviour in Prader-Willi Patients: A Multi-Center, Randomized, Placebo-Controlled Study

BiosciAbstracts