hrp0098p1-67 | Growth and Syndromes 1 | ESPE2024

Study of genetic variability in a cohort of familial growth retardation

Sophie Lambert Anne , Rio Agathe , Laddada Lilia , Lopez Maureen , Girerd Barbara , Bouligand Jerome , Linglart Agnes

Growth failure is the gateway to a myriad of childhood and adolescent diseases. In the majority of cases, growth retardation is said to be constitutional after a detailed diagnostic evaluation. In the literature, there is a high degree of heritability of height (> 80%), underlining the predominant role of genetic factors.Objective: To identify new causes of growth retardation in 61 patients with constitutional familial short stature b...