ESPE Abstracts

Background: Obesity is one of these chronic diseases that makes difficulties in achieving a therapeutic effect and maintaining the obtained effect both in respect of lost kilograms and preventing from the development of its associated diseases. The children's population has the primacy of development of this disease. Surgical treatment is an alternative and in many cases the only right solution to ineffective conservative treatment. It is one of the stage...

Background: Achondroplasia is a genetic disorder that belongs to a large group of skeletal dysplasias that is caused by a missense mutation in the gene encoding FGFR-3 resulting in its constitutive upregulating. This interferes with the receptor's tyrosine kinase domain causing inhibition of cartilage tissue cells and the formation of abnormalities in the bone growth plate leading to defective skeletal development and a disproportionately short stature wi...