hrp0094p1-168 | Growth B | ESPE2021

Mother’s smoking during pregnancy influence intrauterine and postnatal growth - the GrowUp 1990 Gothenburg cohort population

Holmgren Anton , Niklasson Aimon , Aronson A. Stefan , Albertsson-Wikland Kerstin ,

Background/Objective: Smoking during pregnancy is known to influence prenatal/postnatal growth of the offspring. We investigated the impact of smoking in the Swedish reference population for new reference for height, weight and BMI, the GrowUp1990Gothenburg cohort.Material/Methods: The study was based on 1907 healthy children (918girls/989boys) born at term in Sweden with Nordic parents and longitudinal growth measurements. 155girls/180b...

hrp0095fc7.4 | Growth and Syndromes | ESPE2022

Novel puberty aligned references for height, weight and BMI -making personalized medicine in paediatric endocrinology possible

Holmgren Anton , Niklasson Aimon , Gelander Lars , FM Nierop Andreas , Albertsson-Wikland Kerstin

Background and Aim: Despite the broad individual variation of pubertal maturation, references traditionally describe growth in relation to just chronological age and not biological age. Hence, growth references for the adolescent period have been of limited usefulness for monitoring individual growth in clinic and for research. Especially for children and adolescents with chronic diseases is there a need to better evaluate if changes in SD-scores just before a...

hrp0095rfc3.6 | Early Life and Multisystem Endocrinology | ESPE2022

Continuous growth reference from 24th week of gestation to 24 months by sex for length, weight, and head circumferences, based on the healthiest of Swedish Birth Registry 1990-99 and the GrowUp 1990 Gothenburg cohort

Niklasson Aimon , Gelander Lars , Holmgren Anton , FM Nierop Andreas , Albertsson-Wikland Kerstin

Background: Since growth patterns change with time due to secular changes, there is a need to regularly update growth references1. We developed the first continuous birth size reference, from gestational age 24weeks with infancy growth references2, computerized 2006 and used in Swedish health care settings and neonatal units. We now aimed to update this reference by exchanging GrowUp1974Gothenburg cohort to a selected population of health...

hrp0095rfc7.1 | Growth and Syndromes | ESPE2022

The grandma X-rays-independent height prediction

German Alina , Albertsson-Wikland Kerstin , Shmoish Michael , Rubin Lisa , Niklasson Aimon , Hochberg Ze'ev

Background/Aim: Parents wanting to predict adult height (AH) often resort to the old practice of doubling a boy’s height at age 2 years or a girl’s height at 18 months. We coined this the ’Grandma prediction’ (GMP1). It provides predictions with mean absolute error (MAE) 5.9 and 5.2, standard deviations of residuals (sdRES) 4.1 and 3.6, and Pearson correlation r=0.68 and 0.67 for boys and girls, respectively. The recent sophist...

hrp0095p1-2 | Adrenals and HPA Axis | ESPE2022

Growth evaluation by applying the QEPS growth model in patients with CAH

Navardauskaite Ruta , Verkauskiene Rasa , Niklasson Aimon , F.M Nierop Andreas , Albertsson-Wikland Kerstin , Holmgren Anton

Objective: Patients with congenital adrenal hyperplasia (CAH) seldom achieve their target height. Early adrenarche may accelerate bone age maturation and affect adult height. The QEPS-growth-model have been used for developing growth references and investigating healthy/pathological growth, however, not before used in individuals with endocrine disorders. This study aimed to evaluate growth patterns in CAH-patients with the QEPS-model.<s...

hrp0092rfc12.6 | Growth and Syndromes (to include Turner syndrome) | ESPE2019

Exploring the Usefullness of a New Type of Pubertal Heigh Reference Based on Growth Aligned or Onset of Pubertal Growth

Albertsson Wikland Kerstin , Niklasson Aimon , Holmgren Anton , Gelander Lars , Nierop Andreas

Background: Height references have been available for decades, although only related to chronological age and not considering the broad individual variation in the timing and tempo of pubertal maturation and growth. Therefore, growth references and growth charts for the adolescent period have been of limited usefulness both for monitoring growth in individuals and for research. To fill this gap, we recently developed a new type of height reference based on gro...

hrp0092p1-119 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Menarche and its Relation to the Pubertal Growth Spurt

Gardstedt Jenni , Niklasson Aimon , Aronson Stefan , Albertsson-Wikland Kerstin , Holmgren Anton

Background: Both timing of menarche and growth patterns have changed with time (secular changes), highlighting the need of updated knowledge in this topic1. Questions how growth is related to menarche are common in pediatric/pediatric endocrine outpatient clinics. The QEPS-growth model makes it possible to conduct detailed analyses of pubertal growth2.Objective: To investigate the relationship betwe...

hrp0092p1-250 | Pituitary, Neuroendocrinology and Puberty (1) | ESPE2019

Correlation Between Pubertal Growth and Testicular Volume in Boys –a Longitudinal Study

Holmgren Anton , Niklasson Aimon , Aronson A. Stefan , Nierop Andreas F.M. , Albertsson-Wikland Kerstin

Background: Few studies have investigated how the pubertal increase in testicular volume (TV) is related to pubertal growth spurt in a longitudinal setting. Increased TV, indicating onset of puberty in boys, mirrors the enhanced testosterone production in the testicles which also give rise to the pubertal growth spurt. The QEPS-growth model makes it possible to conduct detailed analyses of pubertal growth and separate total growth into specific pubertal (P-fun...

hrp0089p1-p117 | Fat, Metabolism and Obesity P1 | ESPE2018

The More Obese – The Less Pubertal Height Gain

Holmgren Anton , Niklasson Aimon , Martinez-Villanueva Julian , Martos-Moreno Gabriel A , Argente Jesus , Albertsson-Wikland Kerstin

Background: In a population of a community-based setting (BMISDS range −3.5 to +4.1), there is a negative linear correlation between childhood BMISDS and pubertal height gain, together with earlier onset of pubertal growth with higher BMISDS for both sexes (1).Objective: To investigate the impact of BMI in childhood on the pubertal pattern of growth for obese children in a clinical setting.Met...

hrp0089p1-p169 | Growth &amp; Syndromes P1 | ESPE2018

A Novel Type of Pubertal Height, Weight, and BMI Reference, Aligned for Onset of Puberty

Albertsson-Wikland Kerstin , Niklasson Aimon , Gelander Lars , Holmgren Anton , Aronson Stefan , Sjoberg Agneta , Lissner Lauren

Context: Specific references for height, weight and BMI that consider the maturation tempo for onset of puberty are lacking worldwide.Aim: To fill the gap, by developing specific pubertal references for heightSDS, weightSDS and BMISDS, all aligned for the individual onset of puberty.Method: Reference population: a subgroup of GrowUp1990Gothenburg cohort of 1572 (763 girls) health...