ESPE Abstracts

This comprehensive literature review identified studies reporting MRI findings related to pituitary volume in children with GHD. Studies were selected for their relevance to clinical correlations involving short stature, GH peak levels, IGF-1 levels, and therapy response.Results: The 30 studies reviewed highlight significant structural abnormalities in the pituitary gland of children GHD. Key findings include anterior pituitary hypoplasi...

Introduction: This review aims to chronologically summarize MRI findings in children with GHD, correlating these changes with clinical characteristics and GH testing results, and IGF-1 levels.Methods: We reviewed MRI studies conducted from 1991 to 2024, focusing on structural and functional brain changes in children with GHD. Data were extracted from various studies and arranged chronologically.<st...

This review summarizes the prevalence and degree of functional brain changes detected by fMRI in Growth Hormone Deficiency (GHD) patients and their clinical associations in studies from 2019 to 2024Results: Author Year Prevalence of F...

Introduction: Idiopathic short stature (ISS) and growth hormone deficiency (GHD) are conditions that can result in various cognitive and behavioral abnormalities. Functional Magnetic Resonance Imaging (fMRI) is a valuable tool for investigating brain functional connectivity and maturity, offering insights into the neurological underpinnings of ISS and GHD. This review summarizes fMRI findings and their clinical associations, highlighting differences in brain m...

Introduction: This review summarizes the genetic findings in Growth Hormone Deficiency (GHD) versus Idiopathic Short Stature (ISS) and their effects on clinical, radiological, and laboratory outcomes.Methods: A literature review was conducted to identify studies reporting genetic findings related to GHD and ISS.Results: Genetic Findings in GHD: Mutations in GH-1, G...

Introduction: This chronological review of MRI studies from 1991 to 2024 ims to summarize the prevalence and degree of MRI-detected structural changes in GHD patients and compare these findings with children having Idiopathic Short Stature (ISS).Methods: Data were extracted from various studies, highlighting key changes and comparisons with ISS.Results: Studies consistently show si...