hrp0092p2-229 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Normalized Pubertal Tempo of Masculinisation and Pubertal Height Gain in Boys With MPHD, Using a Physiological Treatment Approach with Low Dose Testosterone and Adequate Dose rhGH

Lundberg Elena , Kriström Berit , Albertsson-Wikland Kerstin

Background: Masculinisation tempo on sex-steroid replacement in boys with multiple pituitary hormone deficiencies (MPHD) and pubertal growth spurts on adequate GH-treatment regimens were unknown in 1989 and are still not optimal.Objective and Hypotheses: A hypothesis driven prototype trial1,2 was initiated in the late 80ies aiming to mimic normal puberty3 regarding both degree and tempo of masculini...

hrp0089p1-p027 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Bone Health in Adolescents Born Small for Gestational Age (SGA)

Petraitiene Indre , Basevicius Algidas , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) are at higher risk for metabolic, hormonal and reproductive problems later in life and about 2–10% of children born SGA do not catch-up in height. All these changes may influence bone mineral density (BMD).Aim: To evaluate hormonal profile and BMD in adolescents born SGA in comparison to their peers born appropriate for gestational age (AGA).Methods: 103 children were e...

hrp0086p1-p485 | Fat Metabolism and Obesity P1 | ESPE2016

What are Early Predictors of Impaired Glucose Tolerance in Children Born SGA?

Petraitiene Indre , Jasinskiene Edita , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) were shown to be at higher risk to later metabolic consequences but early prediction factors of changes in glucose metabolism are not clearly known.Objective and hypotheses: We aimed to investigate glucose tolerance and insulin resistance in adolescents born SGA or appropriate for gestational age (AGA) and their relationship with perinatal and postnatal factors.Method: A pro...

hrp0082p1-d3-166 | Growth (2) | ESPE2014

Short-Term Changes in Bone Formation Markers Following GH Treatment in Short Prepubertal Children with a Broad Range of GH Secretion

Andersson Bjorn , Swolin-Eide Diana , Magnusson Per , Albertsson-Wikland Kerstin

Background: GH promotes longitudinal growth and bone modeling/remodeling. The bone formation markers intact amino-terminal propeptide of type 1 procollagen (PINP), bone-specific alkaline phosphatase (BALP), and osteocalcin reflect different stages in bone formation, i.e. proliferation with collagen synthesis, matrix maturation, and mineralization.Objective: The purpose was to study the time course of different bone formation markers during GH treatment i...

hrp0082p2-d1-411 | Growth Hormone | ESPE2014

Spontaneous Baseline GH Secretion Signalling as a Regulator of Bone Metabolism in Children

Decker Ralph , Andersson Bjorn , Nygren Anders , Albertsson-Wikland Kerstin

Background: GH is secreted in a pulsatile manner. The resulting GH peaks are known to be associated with growth, whereas the trough levels between the peaks are thought to be associated with metabolism in different tissues. GH trough levels were identified as a metabolically active signal in rats in the 1980th leading to differences in fat patterning with central obesity. Obese children are known to have low bone mass and bone mass is reduced in short children.<p class="ab...

hrp0084p1-14 | Bone | ESPE2015

No Secular Trend in Vitamin D Levels Over the Past 30 Years in Swedish Children

Andersson Bjorn , Albertsson-Wikland Kerstin , Swolin-Eide Diana , Magnusson Per

Background: The importance of vitamin D for skeletal health is well established and many recent reports indicate that vitamin D deficiency is linked to chronic diseases. Vitamin D status is defined by serum 25-hydroxyvitamin D (25(OH)D), and although there is no consensus on optimal levels of 25(OH)D concentrations of 50 nmol/l (20 ng/ml) meet the requirements in 97.5% of the population. In Sweden, sun cannot synthesize vitamin D during the winter, therefore supplementation is...

hrp0094p1-167 | Growth B | ESPE2021

Sex differences in growth response to GH treatment: more prepubertal and less pubertal gain in girls diagnosed with IGHD, ISS, SGA. Analysis of data from GH-SAFETY-database, including all children treated with rhGH- 1986-2009 in Sweden, in National-GH-Registry and rhGH-clinical-trials.

Lundberg Elena , Kristrom Berit , Pivodic Aldina , Albertsson-Wikland Kerstin ,

Background: Due to fewer girls than boys being GH-treated, after 50yrs the knowledge about sex-differences in both GH-response and GH-responsiveness before and during puberty remains limited.Aim: To describe factors explaining growth response to GH-treatment, separately in girls and boys from GHstart to adult height (AH).Methods: Children diagnosed with IGHD/ISS/SGA from GH-SAFETY-...

hrp0094p1-168 | Growth B | ESPE2021

Mother’s smoking during pregnancy influence intrauterine and postnatal growth - the GrowUp 1990 Gothenburg cohort population

Holmgren Anton , Niklasson Aimon , Aronson A. Stefan , Albertsson-Wikland Kerstin ,

Background/Objective: Smoking during pregnancy is known to influence prenatal/postnatal growth of the offspring. We investigated the impact of smoking in the Swedish reference population for new reference for height, weight and BMI, the GrowUp1990Gothenburg cohort.Material/Methods: The study was based on 1907 healthy children (918girls/989boys) born at term in Sweden with Nordic parents and longitudinal growth measurements. 155girls/180b...

hrp0095fc7.4 | Growth and Syndromes | ESPE2022

Novel puberty aligned references for height, weight and BMI -making personalized medicine in paediatric endocrinology possible

Holmgren Anton , Niklasson Aimon , Gelander Lars , FM Nierop Andreas , Albertsson-Wikland Kerstin

Background and Aim: Despite the broad individual variation of pubertal maturation, references traditionally describe growth in relation to just chronological age and not biological age. Hence, growth references for the adolescent period have been of limited usefulness for monitoring individual growth in clinic and for research. Especially for children and adolescents with chronic diseases is there a need to better evaluate if changes in SD-scores just before a...

hrp0095rfc3.6 | Early Life and Multisystem Endocrinology | ESPE2022

Continuous growth reference from 24th week of gestation to 24 months by sex for length, weight, and head circumferences, based on the healthiest of Swedish Birth Registry 1990-99 and the GrowUp 1990 Gothenburg cohort

Niklasson Aimon , Gelander Lars , Holmgren Anton , FM Nierop Andreas , Albertsson-Wikland Kerstin

Background: Since growth patterns change with time due to secular changes, there is a need to regularly update growth references1. We developed the first continuous birth size reference, from gestational age 24weeks with infancy growth references2, computerized 2006 and used in Swedish health care settings and neonatal units. We now aimed to update this reference by exchanging GrowUp1974Gothenburg cohort to a selected population of health...