hrp0095rfc11.2 | Late Breaking | ESPE2022

Dynamics of meal-related plasma asprosin levels

Corica Domenico , Pepe Giorgia , Aversa Tommaso , Currò Monica , Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Ientile Riccardo , Wasniewska Malgorzata

Background: Asprosin is an adipokine involved in glucose homeostasis and its plasma levels physiologically increases in fasting conditions and decreases with refeeding. In non-diabetic children and adolescents with obesity, insulin resistance (IR) and impaired fasting glucose (IFG) seem to influence the physiological variation in meal-related asprosin levels 120 minutes after an oral glucose load (Corica et al. doi:10.3389/fendo.2021.805700). No data ...

hrp0095t20 | Section | ESPE2022

Sensitivity to thyroid hormones and cardiometabolic risk in euthyroid obese children: a cross-sectional study.

Tropeano Angelo , Corica Domenico , Lorenza Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Pepe Giorgia , Aversa Tommaso , Wasniewska Malgorzata

Background: The typical biochemical phenotype related to obesity, that is high serum thyrotropin (TSH) within normal range, low/normal free thyroxine (FT4) and increased free triiodothyronine (FT3) levels, can be interpreted as a resistance to thyroid hormones. It is unclear the role played by thyroid hormones in the pathogenesis of metabolic derangement associated with obesity.Aim: To investigate the association between...

hrp0092p1-346 | Fat, Metabolism and Obesity (2) | ESPE2019

Non-Invasive Assessment of Liver Steatosis: Usefulness of Elastography in Obese Children – a Pilot Study.

Corica Domenico , Aversa Tommaso , Bottari Antonio , Pepe Giorgia , Morabito Letteria , Curatola Selenia , Spinuzza Antonietta , Alibrandi Angela , Ascenti Giorgio , Wasniewska Malgorzata

Introduction: Non-alcoholic fatty liver disease (NAFLD) is diagnosed in up to 60% of overweight children. Diagnosis and management of NAFLD is challenging due to the lack of non-invasive imaging biomarkers. Ultrasound (US) is the most widely non-invasive method used to identify liver steatosis, however it has low sensitivity to detect mild steatosis and to quantify hepatic fibrosis. Liver Elastography (LE) is a non-invasive methodology used to evaluate hep...

hrp0089p2-p137 | Fat, Metabolism and Obesity P2 | ESPE2018

Severity, Duration and Phenotype of Obesity Promote Precocious Cardiovascular Sonographic Alterations in Childhood Obesity

Corica Domenico , Aversa Tommaso , Oreto Lilia , Calabro Maria Pia , Longobardo Luca , Catalfamo Marta , Alibrandi Angela , Luca Filippo De , Wasniewska Malgorzata

Introduction: Childhood obesity is known to be associated with an increased risk of cardiovascular and metabolic complications in adulthood.Objectives: To evaluate precocious cardiovascular sonographic modifications in a cohort of overweight (OW) and obese (OB) children and adolescents brought to Outpatient Clinic of Pediatric Endocrinology for first evaluation, compared with normal weight controls. 2) To investigate the association between clinical and ...

hrp0094p1-73 | Fetal Endocrinology and Multisystem Disorders A | ESPE2021

Minipuberty in born small for gestational age infants: a case control prospective pilot study

Pepe Giorgia , Calafiore Mariarosa , Velletri Maria Rosa , Corica Domenico , Aversa Tommaso , Mondello Isabella , Alibrandi Angela , Wasniewska Malgorzata ,

Objective: Minipuberty (MP) is still not well defined in small for gestational age (SGA) infants, due to controversial literature data. The present study aims to evaluate MP in SGA infants, both preterm and full-term, compared with those born adequate for gestational age (AGA), during the first year of life.Design: Case-Control, Prospective Study.Methods: The study population included 33 SGA newbor...

hrp0094p1-97 | Thyroid A | ESPE2021

The association between serum Thyrotropin within the reference range and cardiometabolic risk in obese children

Tropeano Angelo , Corica Domenico , Curatola Selenia L. , Pomi Alessandra Li , Casto Celeste , Pepe Giorgia , Aversa Tommaso , Alibrandi Angela , Wasniewska Malgorzata ,

Background: The adaptative increase of serum thyrotropin (TSH) levels in obese subjects may affect the metabolic regulation of body tissues and thus promote an unfavorable cardiometabolic profile.Aim: To investigate the association between serum TSH, free thyroxine (FT4) and cardiometabolic risk factors in euthyroid obese children and adolescents.Material and Methods: Four hundred ninety-one Caucas...

hrp0094p2-189 | Fat, metabolism and obesity | ESPE2021

Prospective evaluation of liver stiffness in obese children: the role of shear wave elastography.

Corica Domenico , Bottari Antonio , Aversa Tommaso , Anna Morabito Letteria , Curatola Selenia , Alibrandi Angela , Ascenti Giorgio , Wasniewska Malgorzata ,

Objectives: The increased incidence of childhood obesity and related non-alcoholic fatty liver disease (NAFLD) has determined the need to identify a non-invasive technique to diagnose and monitor NAFLD. Two-dimensional shear wave elastography (2D-SWE) has emerged as a reliable, non-invasive, tool to evaluate liver tissue elasticity in clinical practice. Aims of this study were to longitudinally evaluate 2D-SWE changes in relation to weight loss, metabolic prof...

hrp0097rfc3.1 | Fat, metabolism and obesity 1 | ESPE2023

Fasting and meal-related zonulin serum levels in a large cohort of obese children and adolescents: a cross sectional study

Pepe Giorgia , Corica Domenico , Currò Monica , Aversa Tommaso , Alibrandi Angela , Bottari Marianna , Ientile Riccardo , Caccamo Daniela , Wasniewska Malgorzata

Background: due to its recently documented role in intercellular tight junction disassembly, zonulin has emerged as a valuable biological marker to assess the integrity of the intestinal mucosal barrier. Experimental studies have shown an association between intestinal permeability and obesity.Objectives: aim of this study was to investigate the relationship between serum zonulin levels, both at baseline and postprandial...

hrp0092p2-182 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Auditory Phenotypes and Dynamics of Hearing Thresholds in 246 Turner Syndrome Females

Aversa Tommaso , Bruno Rocco , Santucci Simona , Messina Maria Francesca , Scarano Emanuela , Borrello Simona , Perri Annamaria , Costa Margherita , Casto Celeste , Alibrandi Angela , Mazzanti Laura , Wasniewska Malgorzata

Objectives: To describe the auditory phenotype and dynamics of hearing thresholds in patients with Turner Syndrome (TS).Patients and Methods: Cross-section study evaluating the hearing thresholds in 246 TS patients (age range 4-44 yrs). Patients were divided into three age groups: Group 1 (79 TS, age range 4.0-12.9 yrs); Group 2 (109 TS, age range 13.0-25.9 yrs,) and Group 3 (66 TS, age range 26.0-44.9 yrs,). Pure tone a...

hrp0092p3-164 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Longitudinal Evaluation of Audiological Pattern in Turner Syndrome

Aversa Tommaso , Bruno Rocco , Santucci Simona , Messina Maria Francesca , Borrello Simona , Scarano Emanuela , Perri Annamaria , Tamburrino Federica , Valenzise Mariella , Alibrandi Angela , Mazzanti Laura , Wasniewska Malgorzata

Objectives: To investigate prognostic markers (age, initial hearing level, karyotype, chronic hormonal therapies, and presence/absence of a mid-frequency dip influence) for hearing loss (HL) in Turner syndrome (TS).Design: Longitudinal cross-sectional and retrospective study.Study Population: 61 TS females (age range 4 - 45 yrs), diagnosed by cytogenetic analysis (49,2% monosom...