hrp0086p1-p46 | Adrenal P1 | ESPE2016

The Effect of Intrauterine Stress on Leukocyte Telomere Length in Newborns

Stefa Alketa , Lamprokostopoulou Agaristi , Kontogeorgou Anna , Briana Despina , Malamitsi-Puchner Ariadne , Tsitsilonis Ourania , Gagos Sarantis , Charmandari Evangelia

Background: Telomeres are specialized nucleoprotein structures located at the ends of chromosomes playing a crucial role in genomic stability. They consist of tandem repeats of the noncoding hexameric TTAGGG sequence. Telomere shortening has been associated with cardiovascular disease, hypertension, type 2 diabetes, atherosclerosis, coronary heart disease and stroke, and has been proposed as a biomarker for ageing and a prognostic factor for age-associated diseases.<p clas...

hrp0086rfc1.3 | Adrenals | ESPE2016

Impaired Cardiac Function in a Mouse Model of Generalized Glucocorticoid Resistance

Lamprokostopoulou Agaristi , Varela Aimilia , Katsimpoulas Michalis , Dimitriou Constantinos , Athanasiadis Nikos , Soultou Eleana , Stefa Alketa , Mavroides Manolis , Davos Constantinos H. , Chrousos George P. , Kino Tomoshige , Georgopoulos Spiros , Charmandari Evangelia

Background: Glucocorticoids regulate a broad spectrum of physiologic functions essential for life and exert their actions through their ubiquitously expressed glucocorticoid receptor (GR). The GR interacts with several molecules, including the non-coding RNA growth arrest-specific 5 (Gas5), which decreases the transcriptional activity of the GR by preventing its binding to DNA, and reduces tissue sensitivity to glucocorticoids.Objective and Hypotheses: T...

hrp0086p1-p7 | Adrenal P1 | ESPE2016

Transient Generalized Glucocorticoid Hypersensitivity Syndrome

Kyritsi Eleni Magdalini , Nicolaides Nicolas C , Lamprokostopoulou Agaristi , Xaidara Athina , Georgiadou Elizabeth , Dimitropoulou Vassiliki , Stefa Alketa , Sertedaki Amalia , Chrousos George P , Charmandari Evangelia

Background: Transient Generalized Glucocorticoid Hypersensitivity (TGGH) is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypoactivation of the hypothalamic┬ľpituitary┬ľadrenal (HPA) axis. The condition itself and the underlying molecular mechanisms have not been fully elucidated.Objective and hypotheses: To present the clinical manifestations, endocrinologic evaluation and molecular studies in ...