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hrp0098p2-229 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Prevalence of neuropsychiatric symptoms in children with central precocious puberty with or without central nervous system lesions.

Almeida Bastos Aline , Pinheiro Machado Canton Ana , Baracho Macena Larissa , Fernandes Pedrosa Ludmila , da Costa Leite Claudia , Bilharino Mendonça Berenice , Nahime Brito Vinicius , Claudia Latronico Ana

Background: Neuropsychiatric symptoms can be present in patients with central precocious puberty (CPP), with or without abnormalities in brain magnetic resonance imaging (MRI). However, they are especially common in those with CPP-related lesions.Aim: To assess the prevalence of brain lesions detected by MRI in a cohort of children with CPP and to evaluate the occurrence of neuropsychiatric manifestations.<p class="a...

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hrp0098p2-240 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Serum MKRN3 levels in girls with central precocious puberty due to MKRN3 loss-of-function mutation

Baracho Macena Larissa , Ribeiro Piovesan Maiara , Almeida Bastos Aline , Fernandes Pedrosa Ludmila , Ribeiro Montenegro Luciana , Pinheiro Machado Canton Ana , Pantaleiou Valassi Helena , Bilharinho Mendonca Berenice , Claudia Latronico Ana , Nahime Brito Vinicius

Background: MKRN3 is known to decline prior to pubertal development in healthy individuals, indicating a potential inhibitor effect on reproductive axis. Currently, MKRN3 loss-of-function mutations represent the main genetic cause of familial central precocious puberty (CPP) in both sexes. The impact of these mutations on MKRN3 serum levels is poorly understood.Aim: To assess serum MKRN3 levels in girls with CPP...

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ESPE Abstracts

Prevalence of neuropsychiatric symptoms in children with central precocious puberty with or without central nervous system lesions.

Serum MKRN3 levels in girls with central precocious puberty due to MKRN3 loss-of-function mutation

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