hrp0098p2-52 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Current challenges in diagnosis, treatment, and follow-up of children with parathyroid hormone dysfunction – lessons learned from a cohort of children presenting with hypocalcaemia

Luzio Vaz Beatriz , Alveirinho Filipa , Simões João , Alves Eduarda , Laura Fitas Ana , Galhardo Júlia , Caetano Francisco , Diamantino Catarina , Limbert Catarina , Lopes Lurdes

Introduction: In hypoparathyroidism and pseudohypoparathyroidism, impaired parathyroid hormone (PTH) function leads to hypocalcaemia, often presenting in children with acute symptoms such as tetany, seizures, hyperreflexia. High-dose calcium supplementation is usually necessary. However, beyond severe symptoms relief, the primary goal of treatment should be to maintain serum calcium levels in the lower quartile of normal range, in order to prevent nephrocalcin...