hrp0086p1-p261 | Diabetes P1 | ESPE2016

Johansson-Blizzard Syndrome with Pan-hypopituitrism, Type 2 Diabetes and Pancreatic insufficiency: Effect of Treatment

Alyafie Fawzia , Soliman Ashraf

Background: Johanson-Blizzard syndrome (JBS) is a disease characterized by poor growth, variable dysmorphic features, including aplasia or hypoplasia of the nasal alae, sensori-neural deafness, abnormal hair patterns or scalp defects, and oligodontia. Other features of JBS include pan-hypopituitarism, imperforate anus, and PI. Pancreatic endocrine insufficiency (PI).Case study: AM is a 10 years-old boy, born at term with aplasia of the alae nasi and cong...

hrp0086p2-p324 | Diabetes P2 | ESPE2016

Glargine versus Detemir Insulin During the Honeymoon Phase in a Child with Type1 Diabetes Mellitus

Alyafie Fawzia , Soliman Ashraf , Elawwa Ahmed

Background: The honeymoon period of type 1 diabetes mellitus (DM1) is characterized by reduced insulin requirements to <0.5 Units/kg per day while maintaining good glycaemic control.Case study: Seven years old boy who was diagnosed with type 1 diabetes mellitus presented with history of polyuria, polydipsia and weight loss for 3 weeks duration. His random Blood glucose=408 mg/dl with initial HBA1C 12.7%. Family history was unremarkable for diabetes ...

hrp0089p2-p201 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Postnatal Growth of Infants with Neonatal Diabetes: Insulin Pump (CSII) Versus Multiple Daily Injection (MDI) Therapy

Alyafie Fawzia , Soliman Ashraf , Sabt Amal , Eldarsy Nagwa , Elgamal Mona

Background: Permanent neonatal diabetes mellitus (PNDM) is a persistent hyperglycaemia diagnosed within the first 6 months of life. A correct genetic diagnosis can affect treatment and clinical outcome. Clinical manifestations at the time of diagnosis include intrauterine growth retardation, hyperglycemia, glycosuria, osmotic polyuria, severe dehydration and failure to thrive. Insulin production is inadequate, requiring exogenous insulin therapy. The treatment corrects the hyp...

hrp0086p2-p292 | Diabetes P2 | ESPE2016

Use of Continuous Glucose Monitoring Helps Selecting Insulin Therapy in Thalassemic Adolescents with Glycemic abnormalities

Soliman Ashraf , Alyafie Fawzia , Yassin Mohamed , Aldarsy Nagwa

Background: Continuous Glucose Monitoring (CGMS) is a useful method to detect the variability of glucose fluctuations and offers the opportunity for better assessment of glucose homeostasis in TM patients and response to therapy.Objective and hypotheses: Does real-life monitoring of blood glucose add to the therapeutic approach to patients with TM who have glycemic abnormalities?Method: In two thalassemic adolescents with glycemic ...

hrp0094p2-416 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Ovarian Juvenile Granulosa Cell Tumor in 9-Month-Old female Infant presented with Isosexual Pseudo Puberty: Case Report

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Alyafie Fawzia , Maadheed Maryam AL , Clelland Colin

Background: In infants, less than 1-year JGCT is extremely rare, with very few reported cases in the literature.Case Report: This 9-month old girl, presented with a day history of bloody vaginal secretions, with an increase in breast size bilaterally 2 months before presentation and growth of fine hair in the genital area. She had no skin hyperpigmentation, no skeletal abnormalities, and no dysmorphic features. On examination, the girl had no dysmorphic ...

hrp0094p2-12 | Adrenals and HPA Axis | ESPE2021

Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH).

Ahmed Shayma , Soliman Ashraf , Alyafie Fawzia , Alaaraj Nada , Hamed Noor , Farag Marwa ,

Introduction: Hyperinsulinaemic Hypoglycaemia (HH) is the most common cause of recurrent and persistent hypoglycemia in the neonatal period. Cortisol and GH play an important role as counterregulatory hormones during hypoglycemia. Both antagonize the peripheral effects of insulin and directly influence glucose metabolism.Patients and Methods: We studied cortisol and GH secretion in newborn infants with HH during spontaneous hypoglycemia....

hrp0094p2-307 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Postnatal Linear Growth and Weight Gain in Infants of Diabetic Mothers (IDM) Who Were Born at or Near Term and Had Severe Neonatal Hypoglycemia Without Other Comorbidities.

Soliman Ashraf , Alaaraj Nada , Alyafie Fawzia , Hamed Noor , Itani Maya , Alneimy Fatma ,

Growth abnormalities at birth and abnormal postnatal pattern of weight gain have been reported in infants born to mothers with gestational diabetes (IDM). This study evaluated the growth pattern from birth to the age of 2 years of 60 IDMs who were born at or near term with significant hypoglycemia. Anthropometric measures (z scores) from birth, 2,4.6,12,18 and 2 years were measured in 60 IDM who presented with significant neonatal hypoglycemia (plasma value less than 20-25 mg/...