hrp0098p2-170 | Growth and Syndromes | ESPE2024

Assessment of Growth Hormone and Gonadotropin-releasing hormone analog combined treatment in patients with Silver-Russell syndrome

Perriere Amelie , Netchine Irène , Giabicani Eloïse

Objective: Silver-Russell syndrome (SRS) is a rare imprinting disorder characterized by growth retardation, advanced puberty and poor pubertal growth spurt leading to short stature. Our aimfor this study was to assess the use of a combined treatment with recombinant human Growth Hormone (rhGH) and Gonadotropin-releasing hormone analog (GnRHa) in patients with SRS followed in the French National Reference Centre, regarding adult height (AH) and tolerance outcom...