hrp0086fc2.4 | Bone & Mineral Metabolism | ESPE2016

In vitro Evidence that Growth Plate Chondrocytes Differentiate into Perichondrial Cells

Spath Stephan-Stanislaw , Andrade Anenisia , Chau Michael , Nilsson Ola

Background: During early bone formation, mesenchymal stem-cells condense and differentiate into collagen type 2-expressing chondrocytes which form the cartilaginous bone anlagen. This anlage becomes enclosed by the perichondrium. The perichondrium consists of two layers, the inner cambium layer containing chondrocyte- and osteo-precursor cells and the outer fibrous layer important for mechanical and structural support. While the regulation of the growth plate is increasingly w...