hrp0095fc1.6 | Thyroid | ESPE2022

Thyroid complications after haemopoietic stem cell transplantation in children and adolescents

Fotiadou Anatoli , Vlachopapadopoulou Elpis-Athina , Paisiou Anna , Goussetis Eugenios , Kafetzi Maria , Karagianni Vilelmini , Peristeri Ioulia , Michalacos Stefanos

Background: Haemopoietic stem cell transplantation (HSCT) has become the treatment of choice for many inherited and acquired pediatric disorders. Cure is not without consequences, and HSCT survivors are at risk of early mortality and developing endocrine complications. Thyroid is highly susceptible to damage from the conditioning therapy for HSCT. The aim of this study is to evaluate the percentage and risk factors of thyroid dysfunction and risk factors of it...

hrp0095p2-46 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Successful treatment with zoledronic acid of a 13-year-old boy with corticosteroid-induced osteoporosis after hematopoietic stem cell transplantation

Athina Vlachopapadopoulou Elpis , Bonataki Myrto , Doulgeraki Artemis , Polyzois Giorgos , Paisiou Anna , Goussetis Eugenios , Peristeri Ioulia , Michalacos Stefanos

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as an increasingly successful option to cure a variety of malignant disorders in children. Children benefit from improved survival; however, HSCT is associated with numerous acute and long-term toxicities. Osteoporosis is a well described, late effect of allogeneic HSCT, associated with corticosteroid treatment and patients exposed to cumulative doses >9000 mg/m2 of prednisone...

hrp0089p2-p399 | Thyroid P2 | ESPE2018

Allogenic Bone Marrow Transplantation in Children: Effect on Thyroid Function

Vlachopapadopoulou Elpis Athina , Paisiou Anna , Stergiotis Stefanos , Ioannidou Eleni Dikaia , Goussetis Eugenios , Kafetzi Maria , Kitra Vassiliki , Michalacos Stefanos

Objective: To report the incidence of thyroid dysfunction of patients who underwent allogenic BMT during childhood.Patients and Methods: Eighty-two patients (56 boys) who were transplanted from an HLA matched donor at a mean age of 7.5±4.8 years (range 0.18–17.5 years) were followed prospectively having measurements of fT4, TSH twice yearly, using chemiluminescence. Patients with elevated TSH higher than 8 μIU/ml had a repeat evaluation in...