ESPE Abstracts

Background: Serious mental and physical retardation are sequelae of untreated congenital hypothyroidism. These complications have become rare since the introduction of neonatal screening in Germany.Case report: Here we report about a girl with congenital hypothyroidism, who suffered from extreme short and thickset stature, rough facial features and straw-like hair at the age of 12 years. She had been detected in newborn screening with a TSH of 132 IU/ml....

Background: In adults it has been shown, that GHmax values after provocation testing are negatively correlated to BMI. Preliminary studies in children have found a similar correlation. Consequently children with elevated BMI would be overdiagnosed with GHD. However, studies so far were too small to define this correlation exactly. This would be a condition to judge whether and to what extend adjustments of GH cut-off levels should be considered also in children with elevated B...

Background/Objectives: Blood amino acid (AA) and acylcarnitine (AC) concentrations are informative on physiological and disease-associated changes in human metabolic pathways. Previously, AAs and ACs were examined as potential biomarkers or predictors of complex metabolic diseases in adults and children. However, there is still a lack of studies examining physiological AA and AC blood levels in healthy paediatric populations. We aimed to assess the intra-perso...