hrp0098p1-102 | Thyroid 1 | ESPE2024

Diagnosis and treatment of a child affected with a novel thyroid hormone receptor alpha (thra) gene mutation

Felicia Faienza Maria , Giardinelli Silvia , Antonio Moscogiuri Luigi , Urbano Flavia , Matera Emilia , Refetoff Samuel

Case report: We describe a 4-year-old girl, born by vaginal delivery after 41 weeks gestational (length: 55 cm, 99thcentile, weight: 4.8 kg, 99th centile). TSH on newborn screen was normal. Evaluated in the first month of life by gastroenterologists for severe constipation required several hospitalizations and investigation by endoscopy, biopsy, and rectal manometry. Constipation was treated by continuous polyethylene glycol administratio...

hrp0098p3-320 | Late Breaking | ESPE2024

Predictive factors of persistent gh deficiency and impact on the final height: a retrospective cohort study

Urbano Flavia , Chiarito Mariangela , Antonio Moscogiuri Luigi , Lattanzio Crescenza , Valerio Giannico Orazio , Annesi Gabriele , Zecchino Clara , Maria Felicia Faienza

Introduction: Most children with isolated GH deficiency (GHD) show a normal GH secretion upon reaching final height (FH). The aimof our study was to identify the predictive factors of persistent GHD and the correlation with the response to recombinant GH (rhGH) therapy in terms of height gain upon reaching FH and compared to target height (TH).Method: In this retrospective study, we evaluated medical records of GHD subje...