ESPE Abstracts

Background: Mauriac syndrome, a rare complication of type I diabetes mellitus (T1DM) results from inadequate glycemic control and excessive insulin therapy. Fluctuating plasma glucose, excessive insulin and glucose administration stimulate glycogen synthase, causing glycogen accumulation in the liver. Furthermore, elevated serum cortisol secretion in Mauriac syndrome inhibits hepatic glycogenolysis while enhancing fatty acid synthesis, worsening liver enlargem...