hrp0098fc15.1 | Late Breaking | ESPE2024

Response to Daily and Weekly Recombinant Human Growth Hormone Treatment in Children Born Small for Gestational Age is Predicted More Accurately by Pre-treatment Blood Transcriptome than Clinical Variables

Garner Terence , Murray Philip , Højby Michael , Ard Ryan , Clayton Peter , Stevens Adam

Background: `(LAGHs) are under investigation to treat SGA. Results from the REAL5 phase 2 trial (randomised, multinational, open-label; NCT03878446) indicate that the LAGH somapacitan has similar efficacy, safety, and tolerability profile as daily GH1. Predicting GH therapy response is critical to improve clinical management of short stature. Here, we compare the prediction of growth response in SGA children treated with daily GH or somapacitan based on ...