hrp0094p2-166 | Diabetes and insulin | ESPE2021

How Does Continuous Glucose Monitoring Systems Effect Metabolic Control In Type 1 Diabetes: Single Center Experience

Arslan Emrullah , ER Eren , Demir Gunay , Isiklar Hafize , Atik Altinok Yasemin , Ozen Samim , Darcan Sukran , Goksen Damla ,

Introduction: Continuous Glucose Monitoring System (CGMS) takes place increasingly in the daily routines of diabetic patients. It has been shown that metabolic control improves when CGMS is used consistently. We aimed to show the effect of CGMS in patients using MDI therapyMaterials - Methods: All patients using multiple-dose insulin therapy at our center and continued their regular follow-up and using CGMS for at least three months were...

hrp0094p2-434 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

A case of gender developmental disorder with difficulty in molecular diagnosis: New variant in NR5A1 gene

Arslan Emrullah , Solmaz Aslı Ece , Aykut Ayca , Durmaz Asude , Atik Tahir , Goksen Damla , Ulman Ibrahim , Ozbaran Burcu , Ozen Samim , Darcan Sukran

"Steroidogenic Factor-1" (SF-1); It is encoded by the NR5A1 gene in 9q 33.3 and regulates the transcription of genes involved in steroidogenesis. It is reported that 46 of the variants in this gene constitute 10-20% of XY sex development disorders (DSD). The patient admitted because of a swelling in the left groin at one month old. She was raised as female. Uterus was 12x2.5 mm in ultrasonography and the gonad in the inguinal region was evaluated as testis. She was P...

hrp0097rfc4.2 | Growth and syndromes (to include Turner syndrome) | ESPE2023

Molecular genetic diagnosis in children with Idiopathic Short Stature: Single Center Experience

Arslan Emrullah , Ece Solmaz Aslı , Avci Enise , Gul Balkı Hanife , Ozalp Kızılay Deniz , Jalilova Arzu , Er Eren , Goksen Damla , Ozen Samim , Darcan Sukran

Introduction: Idiopathic short stature(ISS) refers to children who are short because there is no identifiable defect in the growth hormone (GH)/insulin-like growth factor(IGF) axis and no other endocrine or genetic disorders. The genetic etiology of ISS in children was investigated in this study using targeted next-generation sequencing(NGS).Method: Eighty patients with short stature of unknown etiology were included in ...

hrp0097p1-455 | Fat, Metabolism and Obesity | ESPE2023

Non-Syndromic Monogenic Obesity and Psychiatric Disorders

Arslan Emrullah , Inan Kaleli Ipek , Ozalp Kızılay Deniz , Ata Aysun , Aykut Ayca , Jalilova Arzu , Goksen Damla , Ozbaran Burcu , Darcan Sukran

Introduction: Childhood obesity has been associated with many physical and mental health problems.A significant relationship has been reported between psychiatric disorders, especially attention deficit hyperactivity disorder(ADHD) in obese patients due to the melanocortin 4 receptor(MC4R) gene variant, and it has been claimed that these two conditions may share common molecular pathways. However, studies on this subject are quite insufficient.<p class="ab...

hrp0097p2-160 | Adrenals and HPA Axis | ESPE2023

Factors Influencing the Final Height of Congenital Adrenal Hyperplasia Patients

Gül Balkı Hanife , Arslan Emrullah , Jalilova Arzu , Özalp Kızılay Deniz , Özen Samim , Gökşen Damla , Darcan Şükran

Introduction: CAH is a common clinical condition with treatment and follow-up challenges. As a result, the adult height of the cases is known to be affected. We aimed to assess the growth and pubertal development of CAH patients and the factors that influence final height.Method: Between 1980-2022, 41 patients diagnosed with CAH were observed at our clinic. Only cases that attained the final height were retrospectively a...

hrp0097p1-76 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of Clinical Characteristics of Patients Diagnosed with Syndromic Obesity

Özalp Kızılay Deniz , Gül Balkı Hanife , Arslan Emrullah , Turkut Tan Türkan , Jalilova Arzu , Işık Esra , Gökşen Damla , Darcan Şükran , Özen Samim

Keywords: Syndromic Obesity, Child, GeneticsObjective: Syndromic obesity is accompanied by dysmorphic findings, motor and mental retardation, and organ anomalies. In this study, we aimed to evaluate the patients who were followed up with a diagnosis of syndromic obesity in our clinic.Materials and Methods: Demographic, clinical, and biochemical data of the patients followed up betwee...

hrp0097p1-265 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of Clinical and Genetic Characteristics of Non-Syndromic Monogenic Obese Patients

Özalp Kızılay Deniz , Durmaz Asude , Arslan Emrullah , Jalilova Arzu , Gül Balkı Hanife , Aykut Ayça , Gökşen Damla , Darcan Şükran , Özen Samim

Keywords: Non-syndromic obesity, single gene disorder, child.Objective: This study aimed to evaluate the clinical characteristics, molecular genetic analysis results, and obesity-related comorbidities of patients with non-syndromic monogenic obesityMaterials and Methods: The results of a targeted next-generation sequence analysis panel (Clinical Exome Solution v2 - SOPHiA GENETICS)...

hrp0095p1-99 | GH and IGFs | ESPE2022

Survey to Investigate Adherence to Growth Hormone Treatment in Children: The Impact of COVID-19 Pandemic

Eren Erdal , Cetinkaya Semra , Denkboy Ongen Yasemin , Tercan Ummuhan , Darcan Sukran , Turan Hande , Aydin Murat , Yavuz Yilmaz Fatma , Kilci Fatih , Sever Eklioglu Beray , Hatipoglu Nihal , Yuksek Acinikli Kubra , Orbak Zerrin , Camtosun Emine , Savas Erdeve Senay , Arslan Emrullah , Ercan, Feyza Darendeliler Oya

Introduction: Treatment adherence is crucial for the success of Growth Hormone (GH) therapy. Non-adherence rates have varied over a wide range from 5% to 80% in the literature. Several factors may have an impact on treatment adherence. Besides, with the COVID-19 pandemic that affected the whole world, there were problems with the hospital admission and routine controls of the patients who used GH treatment.Objective: The...

hrp0097p1-177 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

The consistency between Assigned Gender and Individual Gender Identity in Disorder of Sex Development Cases: Long-Term Results from a Single Center

Jalilova Arzu , Özen Samim , Yuluğ Taş Begüm , Kızılay Özalp Deniz , Ece Solmaz Aslı , Gül Balkı Hanife , Tekin Ali , Arslan Emrullah , Atik Tahir , Gülpınar Kübra , Çoğulu Özgür , Ünal Kocabaş Gökçen , Özbaran Burcu , Onay Hüseyin , Ulman İbrahim , Özkınay Ferda , Saygılı Füsun , Gökşen Damla , Darcan Şükran

Introduction: In cases of disorder of sex development (DSD), the change between the gender assigned at birth and the individual's chosen gender identity can occur especially after puberty.Aim: was to determine the relationship between genetic sex, gender assigned at birth and gender identity, and the importance of molecular diagnosis.Method:154patients older than 14years of ag...