hrp0084p2-314 | DSD | ESPE2015

Pubertal Virilization in Two Unrelated XY Teenagers with Female Phenotype due to NR5A1/SF-1 Gene Mutation

Philibert Pascal , Fenichel Patrick , Dewailly Didier , Audran Francoise , Fauconnet-Servant Nadege , Paris Francoise , Sultan Charles

Background: Pubertal virilization in a 46,XY DSD patient is generally due to partial androgen insensitivity, 5-alpha-reductase deficiency, or 17-ketoreductase deficiency. Recently, reports have identified virilization signs associated with NR5A1/SF-1 gene mutations.Cases presentation and method: We present two unrelated cases of pubertal virilization due to NR5A1/SF-1 gene mutation. Both were suspected to be primarily affected by 5-alph...

hrp0084p2-316 | DSD | ESPE2015

Partial Androgen Insensitivity: Syndrome or Symptoms?

Charles Sultan , Pascal Philibert , Nicolas Kalfa , Laurent Maimoun , Francoise Audran , Nadege Servant , Laura Gaspari , Francoise Paris

Background: Partial androgen insensitivity syndrome (PAIS) covers a large spectrum of phenotypes, with the common denominator being insufficient virilisation of the external genitalia in an XY child with normal testosterone (T) production. Genetic diagnosis of PAIS is based on the identification of an androgen receptor (AR) gene mutation.Aim: The aim of this work was to determine whether the PAIS-like phenotype is associated with other gene mutations.</p...

hrp0084p2-321 | DSD | ESPE2015

Familial Mutation of NR5A1/SF-1 Gene Associated with DSD and Spleen Agenesis: A New Syndrome?

Philibert Pascal , Poulat Francis , Audran Francoise , Cartigny Maryse , Paris Francoise , Sultan Charles , Manouvrier-Hanu Sylvie

Background: A recent report (JCI, 2014) described a new homozygous NR5A1/SF-1 mutation in a patient with XY DSD and spleen agenesis. To date, no other data have confirmed this association, raising the hypothesis of fortuity.Case presentation and method: We had the opportunity to study an adolescent girl referred for virilisation during puberty. She presented voice deepening and clitoral hypertrophy. Biological investigations showed high plasma testostero...

hrp0084p2-326 | DSD | ESPE2015

Prevalence of Partial Androgen Insensitivity Syndrome in 3 Cohorts of 46,XY Children Presenting with Isolated Hypospadias, Isolated Micropenis or Isolated Persistent Pubertal Gynecomastia

Francoise Paris , Pascal Philibert , Laura Gaspari , Francoise Audran , Nicolas Kalfa , Charles Sultan

Background: The clinical diagnosis of partial androgen insensitivity syndrome (PAIS) should be systematically considered for all 46,XY newborns/infants with undervirilisation contrasting with normal/elevated plasma testosterone levels. Confirmation of PAIS is based on the identification of an androgen receptor (AR) gene mutation.Aim: This work was undertaken to determine whether the minor forms of undervirilisation such as isolated hypospadias, isolated ...

hrp0084p3-786 | DSD | ESPE2015

Isolated Persistent Pubertal Gynecomastia in Three Adolescent Males as the Only Phenotypic Expression of PAIS with Androgen Receptor Gene Mutations

Philibert Pascal , M'Bou Felicien , Audran Francoise , Gaspari Laura , Paris Francoise , Sultan Charles

Background: Pubertal gynecomastia is observed in up to 65% of adolescent males. It is usually idiopathic and tends to regress within 1–2 years, although sometimes pubertal gynecomastia persists.Case presentation and methods: We investigated three adolescent males with isolated persistent pubertal gynecomastia: twin brothers and an unrelated adolescent boy. The twins (17 years) had normal male external genitalia. Biological testing showed normal test...

hrp0082p1-d3-96 | Sex Development | ESPE2014

Isolated Hypospadias and Exposure to Endocrine Disrupting Chemicals During Pregnancy: a Multi-Institutional Controlled Study in a High Prevalence Area

Kalfa Nicolas , Philibert Pascal , Broussous Sylvie , Chouikh Taieb , Masmoudi Mohamed , Audran Francoise , Paris Francoise , Servant Nadege , Sultan Charles , Orsini Mattea , Zahhaf Amel , Daures Jean Pierre , Lehors Helene , Guys Jean Michel , Reynaud Rachel , Alessandrini Pierre , Bastiani Florence , Kurzenne Jean Yves , Wagner Kathy , Lacombe Gerard Morisson

Background: Numerous studies focused on the association between hypospadias and Endocrine Disrupting Chemicals (EDC) exposures. The wide variability of phenotypes included in these studies, the absence of comparison groups representative of the populations and the absence of concomitant genetic testing to rule out another cause make the results questionable.Objective and hypotheses: We performed a prospective phenotype-specific analysis of patients with ...

hrp0084lbp-1264 | Late Breaking Posters | ESPE2015

Family History of Genital Malformation is Under-Estimated in Children with Isolated Hypospadias: A Clinical Report of 105 Families

Kalfa Nicolas , Philibert Pascal , Broussous Sylvie , Gaspari Laura , Coffy Amandine , Fauconnet-Servant Nadege , Audran Francoise , Lehors Helene , Guys Jean Michel , Reynaud Rachel , Merrot Thierry , Wagner Kathy , Breaud Jean , Kurzenne Jean Yves , Bastiani Florence , Valla Jean Stephane , Dobremez Eric , Daures Jean-Pierre , Paris Francoise , Sultan Charles

Background: Severe forms of 46,XY DSD with uncertain sex may have a family history (FH) in ~15–20% of cases. On the other side of the DSD spectrum, data regarding isolated hypospadias is sparse and a FH of genital malformation is thought to be less frequent.Objective and hypotheses: The aims of the study were i) to determine the frequency of genital abnormalities in families of isolated hypospadiac boys, ii) to determine whether there is a particula...