hrp0095p1-419 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Early-Stage Radiological Markers of Endothelial Dysfunction and Cardiovascular Findings in Patients with Osteogenesis Imperfecta and Their Genotype-Phenotype Correlations: A Case-Control Study

Evin Ferda , Aydin Derya , ÖZen Samim , Darcan Şükran , Onay Hüseyin , Gökşen Damla , Levent Ertürk

Introduction: Osteogenesis imperfecta (OI) is a disease related to collagen synthesis or fuctions. Collagen is found in many areas of the cardiovascular system. Endotelial dysfunction can be detected at an early stage before the symptoms become evident by non-invasive radiologic methods such as flow-mediated dilatation (FMD), carotid intima-media thickness (CIMT), and ventricular functions measurements, which may serve as indicators of endothelial dysfunction....