hrp0092p2-157 | GH and IGFs | ESPE2019

Long-Term Follow-Up of Three Patients with Isolated Growth Hormone Deficiency Type IA Withsustained Growth Response to rhGH

Makretskaya Nina , Babinskaya Svetlana , Chikulaeva Olga , Tiulpakov Anatoly

Background: Isolated growth hormone deficiency type IA (IGHD IA) is described in families with homozygous GH1 deletions that arise from unequal recombination and crossing over within the GH gene cluster during meiosis. Patients with IGHD IA show early and severe growth failure and tend to develop antibodies upon treatment with recombinant human growth hormone (rhGH).Aims: To present the follow−up of three ...