hrp0092p1-238 | Multisystem Endocrine Disorders | ESPE2019

Positive correlation between circulating irisin concentrations and homeostatic model assessment for insulin resistance (HOMA-IR) in women with Polycystic Ovary Syndrome: a Meta-analysis

Bacopoulou Flora

Background: Irisin has emerged as a potential mediator of energy expenditure that may improve adiposity and glucose homeostasis. Irisin's metabolic benefits in animal models are convincing, but only promising regarding humans. Irisin's secretion by and its potential roles in several tissues have been associated with insulin resistance (IR). In modern societies, health problems associated with IR are quite common. One such condition, the enigmatic polyc...

hrp0092p1-242 | Multisystem Endocrine Disorders | ESPE2019

Basal Metabolic Rate in Polycystic Ovary Syndrome: A Meta-Analysis

Geronikolou Styliani , Kanaka-Gantenbein Christina , Bacopoulou Flora

Background: While polycystic ovary syndrome (PCOS) is implicated with insulin resistance and obesity, little is known about the abnormal energy imbalance contribution to the disease. Basal metabolic rate (BMR) represents the energy expenditure by a normal subject at rest, remote from eating, in a thermally neutral environment, reflecting the 50–70% of total daily metabolism. The relevant literature is limited with conflicting results- worth meta-analy...

hrp0092p2-58 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Skeleton Muscles and Tissues Metabolic Activity in Greek Adolescent PCOS

Geronikolou Styliani , Cokkinos Dennis , Bacopoulou Flora

Background: The skeleton, which is strongly controlled by endocrine factors, has recently been shown to play an active endocrine role itself, specifically influencing energy metabolism. However, its role in polycystic ovary syndrome (PCOS) phenotype is underinvestigated.Aim: Herein, we sought to identify novel factors involved in the regulation of both bone mass and whole-body homeostasis relevant to the disease.<p c...

hrp0092p2-213 | Multisystem Endocrine Disorders | ESPE2019

Heart Rate Variability in Adolescent Polycystic Ovary Syndrome Greek Patients

Geronikolou Styliani , Cokkinos Dennis , Bacopoulou Flora

Background: The polycystic ovary syndrome (PCOS) is believed to contribute to adverse cardiovascular effects.Aim: The aim of the present study was to investigate the potential alterations in heart rate variability (HRV) pattern in adolescent patients with polycystic ovary syndrome (PCOS).Methods: Nineteen PCOS adolescent patients group (mean age 16.8 ± 3.2 years) and twenty on...

hrp0089p3-p281 | Multisystem Endocrine Disorders P3 | ESPE2018

Basal Metabolic Rate as Moderator of Inflammation in PCOS

Geronikolou Styliani , Cokkinos Dennis , Bacopoulou Flora

This prospective population study focuses on metabolic differences between adolescent patients with polycystic ovary syndrome (PCOS) and age/BMI matched non-PCOS controls recruited by the Centre for Adolescent Medicine and UNESCO Chair on Adolescent Health Care of the First Department of Paediatrics, at the ‘Aghia Sophia’ Children’s Hospital, in Athens, Greece. Bioimpendance is an established non-interventional method for the determination of the body compositio...

hrp0089p2-p297 | Multisystem Endocrine Disorders P2 | ESPE2018

Polycystic Ovary Syndrome Metabolic Syndrome Predisposition in Puberty

Geronikolou Styliani , Bacopoulou Flora , Chryssanthopoulos Stavros , Cokkinos Dennis

This case control study aims at investigating the cardiovascular profile of Greek adolescents suffering from polycystic ovary syndrome (PCOS) by comparing them with age- and body mass index (BMI)- matched non-PCOS controls. Nineteen PCOS patients and eighteen non-PCOS controls (aged 13 to 23 years) were studied for: (i) bioreflex sensitivity (BRS), as a marker of cardiac function, (ii) carotid pulse pressure (PP) and subendocardial viability ratio (SEVR), as markers of arteria...

hrp0086fc7.2 | Gonads &amp; DSD | ESPE2016

Serum Irisin Concentrations in Lean Adolescents with Polycystic Ovary Syndrome

Bacopoulou Flora , Athanasopoulos Nikos , Mantzou Aimilia , Efthymiou Vassiliki , Lambrou George

Background: The myokine irisin, is associated with the metabolic and hormonal dysregulation of polycystic ovary syndrome (PCOS) in adult women. Recent studies have shown that circulating irisin levels increase in adult women with PCOS.Objective and hypotheses: The purpose of this study was to determine serum concentrations of irisin in lean adolescents with PCOS and healthy controls and to evaluate correlations with clinical, sonographic and hormonal par...

hrp0094p2-344 | Multisystem endocrine disorders | ESPE2021

Thermoregulatory delays in Greek PCOS adolescents

Geronikolou Styliani , Chrousos George , Cokkinos Dennia , Bacopoulou Flora ,

In this case-control study 19 Greek adolescents with Polycystic Ovary Syndrome (PCOS) and 21 non-PCOS controls were assessed for their hormonal, somatometric and autonomic nervous system profile in supine position. The study adhered to the Helsinki Guidelines of Good Clinical Practice. Significant differences were found only in very low frequencies (VLF) (P = 0.008) and Power spectral density RR (PSD) (P < 0.001) between adolescents with PCOS and controls...

hrp0092p1-198 | Fat, Metabolism and Obesity (1) | ESPE2019

Correlation of Serum Chemerin Concentrations with Obesity/Metabolic Syndrome Characteristics in Pre-Adolescents and Adolescents

Bacopoulou Flora , Koutroumpa Arsinoi , Zoi Vasiliki , Karatza Eleni , Karalis Vangelis , Markantonis Sophia , Siahanidou Tania

Background: Chemerin, a protein mainly synthesized in the adipose tissue and liver, belongs to the adipokines family and is implicated in signaling for adipocyte differentiation and lipolysis. From this point of view, chemerin can exert an important role in the regulation of various pathophysiological functions, including lipogenesis and metabolism.Objective: The aim of this study was to investigate the relationship betw...

hrp0092p3-275 | Late Breaking Abstracts | ESPE2019

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Normal-Weight, Overweight and Obese Adolescent Females

Bacopoulou Flora , Apostolaki Despoina , Mantzou Aimilia , Doulgeraki Artemis , Pałasz Artur , Koniari Eleni , Efthymiou Vasiliki

Background: The Spexin gene is considered the most dysregulated in obese human fat with an almost complete absence of expression in obese human fat in comparison with non-obese fat tissues. Limited data from human and animal studies suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity.Objective: The aim of this study was to compare serum spexin concentrations betw...