hrp0086p2-p412 | Gonads & DSD P2 | ESPE2016

Towards the Roles of Kisspeptins in the Control of Gonadotropic Axis: Focus on Peripheral Signaling in Androgen-Dependent Tissues in the Experimentally Induced Model Hypogonadotropic Hypogonadism in Male Rats

Nikitina Irina , Khoduleva Yulia , Nagornaya Irina , Bairamov Alekber , Shabanov Petr , Masel Alisa

Background: Recently kisspeptins are considered as a key gatekeepers of the regulation of the gonadotropic axis.Objective and hypotheses: To investigate the impact of experimentally induced hypogonadism on kisspeptins signaling in androgen-dependent tissues and blood.Method: Wistar male rats (29 in total) were used. Rats were divided into four groups. Group 1 (control, prepubertal rats aged 2 months, n=7). Group 2 (control...