hrp0086fc13.3 | Management of Obesity | ESPE2016

Hypothalamic Gliosis in Obese Children and Adolescents

Sewaybricker Leticia E , Cendes Fernando , Schur Ellen A , Melhorn Susan J , Barbosa Silene M , Mendes Roberto T , Velloso Licio A , Guerra-Junior Gil

Background: Obesity is a persistent disorder that almost universally recurs following treatment, suggesting a disruption on central nervous system control over energy homeostasis. Recent literature suggests that hypothalamic inflammation may have an important role on obesity pathogenesis. This inflammatory reaction, which histologically appears as a reactive gliosis, may be detected using magnetic resonance imaging (MRI), and has just been shown in rodent models and adults.</p...