hrp0082p2-d3-388 | Fat Metabolism & Obesity (2) | ESPE2014

Metformin Treatment in Obese Children Enhances Weight Loss Related Improvement in Impaired Glucose Tolerance

Bartucci Andrea , Martos-Moreno Gabriel A. , Barrios Vicente , Argente Jesus

Background: Impaired glucose tolerance ((IGT), glucose ≥140mg/dl at 120’ in the oral-glucose-tolerance-test (OGTT)) is prevalent in childhood obesity. It is frequently reversed after weight loss, although an eventual role for metformin treatment has been postulated.Objective: To evaluate the benefits of metformin addition to conservative treatment on weight loss and IGT in obese children.Patients and methods: We studied ...

hrp0092fc15.6 | Late Breaking Abstracts | ESPE2019

Leptin Influences the Down-Regulation of UCP-1 Expression in Brown Adipose Tissue During Negative Energy Balance

Barrios Vicente , Canelles Sandra , Frago Laura M. , Chowen Julie A. , Argente Jesús

Background: The GH/IGF-I axis is involved in metabolic control and studies suggest that IGF-I deficiency and subsequent changes in IGF-I signaling in brown adipose tissue (BAT) modifies its thermogenic capacity. Food restriction reduces thermogenic capacity in BAT, while leptin stimulates thermogenesis through uncoupling protein 1 (UCP-1) induction. Leptin and IGF-I maintain important crosstalk in different tissues, but whether these two hormones interact to r...

hrp0082p2-d1-371 | Fat Metabolism & Obesity | ESPE2014

Replacement of the Neonatal Leptin Surge During Maternal Deprivation Normalizes Some Endocrine Parameters but Exacerbates Others

Mela Virginia , Lopez-Rodriguez Alvaro , Penasco Sara , Barrios Vicente , Argente Jesus , Viveros Maria-Paz , Chowen Julie A

Introduction: Maternal deprivation (MD) during neonatal life has diverse long-term effects, including modification of metabolism. Some of these effects are sexually dimorphic. We have previously reported that MD in rats blocks the physiological neonatal leptin surge, which could underlie the long-term metabolic changes.Hypothesis: We hypothesized that replacement of leptin during MD would normalize long-term endocrine changes.Metho...

hrp0084p3-859 | Fat | ESPE2015

Long-Term Effects of Neonatal Over-Nutrition on Metabolic Equilibrium are Age and Sex Dependant

Argente-Arizon Pilar , Ros Purificacion , Diaz Francisca , Fuente-Martin Esther , Barrios Vicente , Chowen Julie A , Argente Jesus

Background: Neonatal over-nutrition (NON) can have a long-term effects on energy homeostasis and some of these effects may be sexually dimorphic.Objective and hypotheses: We aimed to determine how NON affects body weight (BW), body composition and cytokine levels throughout development and if these changes are sexually dimorphic. We hypothesised that the effects would be both age and sex dependant.Methods: At birth, Wistar rats wer...

hrp0094p2-281 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Endocrinological assessment in patients with fanconi anemia

Corredor-Andres Beatriz , Martin-Rivada Alvaro , Zubicaray Josune , Barrios Vicente , Sevilla Julian , Argente Jesus ,

Introduction: Fanconi anemia (FA) is a rare genetic disease that presents with aplastic anemia. Around 60% have short stature (SST), with a mean height of -2.2 SD. However, studies assessing the etiology of SST not having reached relevant conclusions.Aim: Our aim was to evaluate the clinical features and endocrine status in relationship to SST in patients with FA.Methods and Patients: A cross-secti...

hrp0084p1-27 | Diabetes | ESPE2015

Activation of Insulin Signaling in Gastrocnemius after Central Leptin Infusion is Associated with an Increase in Proliferation and Muscle Fibre Size

Barrios Vicente , Burgos-Ramos Emma , Canelles Sandra , Rodriguez Amaia , Gomez-Ambrosi Javier , Chowen Julie A , Fruhbeck Gema , Argente Jesus

Background: Skeletal muscle is the largest tissue involved in the insulin-stimulated disposal of glucose, with its size being controlled by hormonal status, among other factors. Leptin plays a primary role in the regulation of glucose homeostasis with a substantial degree of insulin and leptin cross-talk in muscle. However, the relationship between the leptin’s central effects on insulin sensitivity in muscle and associated structural changes remain unclear.<p class="...

hrp0094p2-248 | Growth hormone and IGFs | ESPE2021

Reduction in pappalysin and stanniocalcin levels explain the decrease in IGF-I bioavailability in anorexia nervosa

Martin-Rivada Alvaro , Guerra-Cantera Santiago , Campillo-Calatayud Ana , Camarneiro Ricardo , Graell Montserrat , Barrios Vicente , Argente Jesus ,

Background: Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) are novel regulators of the GH-IGF axis, modulating IGF bioavailability through control of cleavage of IGFBPs and release of IGF from the ternary complex. Changes in the peripheral IGF system, including low IGF concentrations independently of GH secretion, have been reported in scenarios of malnutrition such as anorexia nervosa (AN). The role of pappalysins and stanniocalcins in the pa...

hrp0092fc8.4 | Pituitary, Neuroendocrinology and Puberty Session 1 | ESPE2019

Peripheral and Hypothalamic Alterations in the Insulin-like Growth Factor (IGF) System in Response to High Fat Diet-induced Weight Gain

Guerra-Cantera Santiago , Díaz Francisca , Ros Purificación , Freire-Regatillo Alejandra , Torrecilla-Parra Marta , Barrios Vicente , Frago Laura , Chowen Julie A. , Argente Jesús

The insulin-like growth factor (IGF) system is fundamental for physiological processes such as growth and metabolism. In addition, in the brain it regulates glucose metabolism and neuroprotection. The IGF axis can be altered by nutritional status, but little is known regarding the effects of specific dietary components on this system.Our aim was to examine how high-fat diet (HFD) and low-fat/high sucrose diet (LFHSD) intake affect the central and circula...

hrp0082p1-d2-69 | Diabetes (1) | ESPE2014

Activation of Insulin/IGF1 Signaling Could Increase Hypothalamic Lipid Anabolism in Non-Diabetic IRS2-Deficient Mice

Barrios Vicente , Baquedano Eva , Canelles Sandra , Gonzalez-Rodriguez Agueda , Burgos-Ramos Emma , Chowen Julie A , Frago Laura M , Valverde Angela M , Argente Jesus

Background: Insulin/IGF1 signaling plays a critical role in central glucose bioavailability and lipid metabolism. An increase in glucose disposal can generate reducing agents through the pentose-phosphate pathway necessary for the synthesis of free fatty acids (FFA). Disturbances in lipid synthesis are related to the appearance of insulin resistance and diabetes. The insulin receptor substrate 2 (IRS2) deficient mice (IRS2−/−) is an excellent model to st...

hrp0084p3-873 | Fat | ESPE2015

Sex Differences in the Pubertal Response to High-Fat Diet

Freire-Regatillo Alejandra , Argente-ARizon Pilar , Diaz Francisca , Barrios Vicente , Arevalo Angeles , Argente Jesus , Garcia-Segura Luis Miguel , Azcoitia Inigo , Chowen Julie A

Background: It is well known that ingestion of a high fat diet (HFD) can induce rapid weight gain and metabolic imbalances. However, males and females are not equally susceptible to these effects. Furthermore, an individual may be more prone to gain weight during specific developmental periods.Aims and objectives: We aimed to analyse the response to the acute exposure to a HFD during pubertal/adolescent period and to determine whether males and females r...