hrp0098rfc11.2 | Fat, Metabolism and Obesity 2 | ESPE2024

Is the Single Point Insulin Sensitivity Estimator (SPISE) index a reliable tool for children and adolescents with overweight/obesity?

Tantari Giacomo , Bassi Marta , Pistorio Angela , Minuto Nicola , Napoli Flavia , Piccolo Gianluca , Spacco Giordano , d'Annunzio Giuseppe , Maghnie Mohamad

Introduction: Pediatric obesity is is increasing worldwide. Children and adolescents affected are at increased risk of Type 2 Diabetes Mellitus and its cardiovascular complications, starting in young adulthood and linked to insulin resistance and its inflammatory milieu. The SPISE index, calculated using baseline triglycerides, HDL cholesterol, and BMI, shows promise in predicting insulin resistance in this population. It is not affected by insulin secretion p...