hrp0086p2-p585 | Perinatal Endocrinology P2 | ESPE2016

Change Level of TRAb in Newborn Leads to Thyroid Dysfunction – Case Report

Sawicka Beata , Borysewicz- Sanczyk Hanna , Bossowski Artur

Maternal new-diagnosed Graves’ disease is quite rare thyroid dysfunction with an estimated incidence of 0.4–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Neonatal hyperthyroidism almost always is transient and results from the transplacental passage of maternal thyrotropin (TSH) receptor stimulating antibodies. Neonates born to mothers with Graves&#146...

hrp0084p3-1221 | Thyroid | ESPE2015

Hyalinizing Trabecular Tumour of Thyroid Gland in 17-Year-Old Boy – Case Report

Sawicka Beata , Dzieciol Janusz , Bossowski Artur

Background: Hyalinizing trabecular tumour is a rare, begin thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma or medullary carcinoma. Sometimes it is misdiagnosed as papillary carcinoma on fine-needle aspiration cytology (FNAC). The aetiology of hyalinizing trabecular tumour is unknown. The tumour may arise in a background of chronic lymphocytic thyroiditis, multinodular goitre, or after radiation exposure. Hyalinizing trabecular adenoma (...

hrp0095p1-187 | Thyroid | ESPE2022

Analysis of miR-15a-5p, miR-126-3p, miR-142-5p and miR-150-5p levels in blood of children and adolescents with thyroid diseases

Sawicka Beata , Sulewska Anetta , Borysewicz-Sańczyk Hanna , Żelazowska-Rutkowska Beata , Bossowski Artur

Background: The pathogenesis of autoimmune thyroid diseases depends on many factors including genetic predisposition and environmental factors. Graves' disease and Hashimoto's thyroiditis are associated with an impaired immunological tolerance to antigen molecules in the thyroid gland. Abnormal immunotolerance results from impaired suppression involving regulatory T cells in peripheral immunocompetent tissues (Tregs). It is known that patients with a...

hrp0095p2-140 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

POU1F1 gene mutation as a cause of central hypothyroidism and growth hormone deficiency: a case report

Sawicka Beata , Borysewicz-Sańczyk Hanna , Sztatyłowicz Aleksandra , Michalak Justyna , Stożek Karolina , Bossowski Artur

Background: Thyroid hormones are necessary for normal child development. Hypothyroidism, associated with insufficient amounts of free triiodothyronine and thyroxine, may not only cause poor growth rate, but also results in impaired central nervous system development. In Poland, newborn screening for congenital primary hypothyroidism, the incidence of which is reported to be 1:2500- 1:4000 births, has been performed for many years. Secondary hypothyroidism, cau...

hrp0092t2 | Top 20 Poster | ESPE2019

Assessment of ZnT8 Antigen in Thyroid Cells in Children and Adolescents with Hashimoto Thyroiditis and Nodular Goitre

Borysewicz-Sańczyk Hanna , Dzięciol Janusz , Sawicka Beata , Bossowski Artur

Introduction: The presence of ZnT8 (zinc transporter 8) has been described on the surface of beta pancreatic cells in type 1 diabetic patients and the ZnT8 Ab (zinc transporter-8 autoantibody) has been recently established as a new marker of this autoimmune disease. There are studies demonstrating that ZnT8 may be of importance in some other endocrine cell types. In our study we wanted to verify the presence of ZnT8 in thyroid cells of children and adolescents...

hrp0092p2-278 | Thyroid | ESPE2019

A 10- Year-Old Girl with Thyroid Hormone Resistance (βTHR)- Case Report

Bossowski Artur , Michalak Justyna , Sawicka Beata , Sanczyk Hanna Borysewicz- , Kolanowska Monika , Kubiak Anna , Jazdzewski Krystian

Introduction: Thyroid hormone resistance (THR) is a rare syndrome which is characterized by reduced response to thyroid hormones at tissue level. The disorder is caused by genetic mutation in the thyroid hormone receptor. The most common are a heterozygous thyroid hormone β (THRβ) gene mutations. Laboratory tests usually show normal or elevated level of thyroid- stimulating hormone (TSH) and high concentration of thyroid hormones (T3 and T4).<p c...

hrp0092p3-167 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Bloom Syndrome in 7-Year-Old Girl Diagnosed with Short Stature

Borysewicz-Sańczyk Hanna , Sawicka Beata , Cottrell Emily , Ladha Tasneem , Storr Helen , Bossowski Artur

Introduction: Bloom syndrome (BS) is a rareautosomal recessive disorder caused by mutations in the BLM gene, located on the long arm of the chromosome 15 (15q26.1). The typical symptoms of the disease are short stature, low birth weight, dysmorphic features including long, narrow face (dolichocephaly), micrognathism and prominent nose and ears. Other characteristic features include a rash following sun exposure, hyper-pigmented areas or cafe-au-lait s...

hrp0089p3-p045 | Bone, Growth Plate &amp; Mineral Metabolism P3 | ESPE2018

Idiopathic Hypoparathyroidism in a 10 Year-Old Girl with Concomitant Epilepsy, Long Q-T Syndrome (LQTS), Pericarditis and Pneumonia

Borysewicz-Sańczyk Hanna , Sawicka Beata , Kiryluk Barbara , Szumowski Piotr , Allgrove Dr. Jeremy , Bossowski Artur

Introduction: PTH is one of the principal regulatory hormones for calcium and phosphate homeostasis. Hypoparathyroidism, caused by reduced parathyroid hormone (PTH) concentration is characterised by hypocalcemia and hyperphosphataemia. Hypoparathyroidism in children can occur either as part of a genetic syndrome, autoimmune disorder, be acquired secondarily to thyroidectomy or some destructive process of the glands. If the reason for decreased PTH concentration is unknown, it ...

hrp0089p3-p224 | Growth &amp; Syndromes P3 | ESPE2018

A 14-Year-Old Boy with Simpson-Golabi-Behmel Syndrome – Case Report

Sawicka Beata , Jakubiuk-Tomaszuk Anna , Borysewicz- Sańczyk Hanna , Michalak Justyna , Bossowski Artur

Simpson-Golabi-Behmel syndrome is a condition which classified as an overgrowth syndrome and affects many parts of the body and occurs primarily in males. Infants have macrosomia at birth and continue to grow and gain weight at an unusual rate. The incidence of Simpson-Golabi-Behmel syndrome is unknown. Mutations in the GPC3 gene are the most common cause of Simpson-Golabi-Behmel syndrome. About 250 people worldwide have been diagnosed with this disorder. About 10 percent of p...

hrp0082p1-d2-23 | Autoimmune Endocrine Disease | ESPE2014

Analysis of Zinc Transporter ZnT8 Autoantibodies in Children and Adolescents with Autoimmune Thyroid Diseases

Bossowski Artur , Borysewicz-Sanczyk Hanna , Glowinska-Olszewska Barbara , Sawicka Beata , Bossowska Anna , Michalak Justyna , Furmaniak Jadwiga

Background: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. Moreover it was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. ZnT8 autoantibodies (ZnT8 Ab) next to glutamic acid decarboxylase antibodies (GAD Ab), insulin autoantibodies (IAA), and islet antigen-2 antibodies (IA-2 Ab) have been described as markers of autoimmune process ...