hrp0098p2-391 | Late Breaking | ESPE2024

QT Interval Dynamics in Transgender/Gender diverse Adolescents on GnRHa and Gender-Affirming Hormonal Therapy: A Comparative Analysis

Zaitoon Hussein , Kapusta Livia , Israeli Galit , Segev-Becker Anat , Beer Gil , Oren Asaf , Perl Liat

Background: The QT interval, corrected for sex and heart rate (QTc), measures the duration of the cardiac action potential and can indicate the risk of arrhythmias. The QT interval is typically longer in women compared to men; a phenomenon often attributed to estrogen's effects. However, conflicting data exist regarding the effects of gonadotropin-releasing hormone agonist (GnRHa) and gender-affirming hormonal treatment (GAHT) on QT intervals and dispersi...