hrp0089p3-p311 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Congenital Hypopituitarism Associated with Complex Cranio-Vertebral Junction Anomalies

Valenzise Mariella , Pitrolo Elda , Biasi Michele , Santucci Simona , Wasniewska Malgorzata , Luca Filippo De

Background: Abnormalities of cervical spine have been described in association with pituitary anomalies in the context of malformative syndromes with midline defects. Several genes are involved in the control of pituitary gland development, differentiation and function. In particular, the presence of os odontoideum has been reported in one case of pituitary hypoplasia, associated with leg anomalies, renal dysplasia and no aberrations of the BMP4, BMP2 and PTX1 genes. In anothe...